| Ertapenem-induced acute pancreatitis in a surgical elderly patient. | |
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MedLine Citation:
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PMID: 18046618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Case summary A 78-year old man was given, after surgery, 1 g ertapenem every 24 h intravenously. His clinical evolution was favorable and on day 8 ertapenem was discontinued and the patient was put on a semi-solid diet. On day 9, abdominal distension was seen accompanied by epigastric pain. The laboratory tests on day 8 showed an altered pancreatic profile: amylase = 1823 U/l (normal value: 0-100); lipase = 8045 U/l (normal value: 0-60); C-reactive protein (CRP) = 16.09 mg/dl (normal value: 0-0.5). Full Blood Count (FBC) showed leukocytosis with an increase in neutrophils and eosinophils. The prior pancreatic parameters were normal without leukocytosis. The evolution of clinical symptoms after discontinuing ertapenem was rapid. Between days 11 and 16, the laboratory parameters returned to normal values; the eosinophilia persisted longer, decreasing between days 14 and 16. Conclusions clinicians should include monitoring the development of acute pancreatitis in the safety parameters in patients undergoing treatment with this carbapenem. |
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Authors:
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Francisco Martínez-Granados; José Noé Navarro; José Luis Estrada; María Teresa Martínez-Lazcano; Félix Lluis-Casajuana; Juan Pablo Ordovás-Baines |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-11-28 |
Journal Detail:
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Title: Pharmacy world & science : PWS Volume: 30 ISSN: 0928-1231 ISO Abbreviation: Pharm World Sci Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-04-17 Completed Date: 2008-10-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307352 Medline TA: Pharm World Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 278-80 Citation Subset: IM |
Affiliation:
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Pharmacy Service, Hospital General Universitario de Alicante, C/ Maestro Alonso, Alicante, Spain. fmartinezgranados@redfarma.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Amylases / analysis Anti-Bacterial Agents / adverse effects* Blood Cell Count Enteral Nutrition Eosinophils Humans Leukocyte Count Lipase / blood Male Pancreatic Function Tests Pancreatitis / chemically induced*, diet therapy beta-Lactams / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/beta-Lactams; 0/ertapenem; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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