Document Detail


Errors in development of fetuses and placentas from in vitro-produced bovine embryos.
MedLine Citation:
PMID:  16266745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro systems for oocyte maturation, fertilization and embryo culture [in vitro production (IVP)] have the potential for more wide-spread use in creative breeding programs for dairy and beef cattle. However, one negative consequence of both IVP and somatic cell nuclear transfer (SCNT) in cattle and other species is that embryos, fetuses, placentas, and offspring can differ significantly in morphology and developmental competence compared with those from embryos produced in vivo. Fetuses and placentas derived from IVP and SCNT embryos may fall within the normal range of development, may have obvious abnormalities such as increased fetal and placental weights, or may have subtle abnormalities such as aberrant development of fetal skeletal muscle, placental blood vessels, and altered metabolism. Failures in physiologic and/or genetic mechanisms essential for proper fetal growth and survival outside of the uterus contribute significantly to pregnancy and neonatal losses. Oversized fetuses are at increased risk of death during parturition and the adverse consequences of severe dystocia may compromise the dam. Collectively, these abnormalities have been referred to as 'large offspring syndrome' or 'large calf syndrome'. Abnormal phenotypes resulting from IVP and SCNT embryos are stochastic in occurrence and they have not been consistently linked to aberrant expression of single genes or specific pathophysiology. Thus, reliable methods of early diagnosis of the condition are not yet available. The objective of this paper is to examine abnormal development of fetuses and placentas resulting from embryos produced using in vitro systems. The term 'abnormal offspring syndrome (AOS)' is introduced and a classification system of developmental outcomes is proposed to facilitate research efforts on the mechanisms of the various abnormal phenotypes. We also discuss potential genetic and physiologic mechanisms that may contribute to abnormal phenotypes following transfer of IVP and SCNT embryos.
Authors:
Peter W Farin; Jorge A Piedrahita; Charlotte E Farin
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-11-02
Journal Detail:
Title:  Theriogenology     Volume:  65     ISSN:  0093-691X     ISO Abbreviation:  Theriogenology     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-91     Citation Subset:  IM    
Affiliation:
Department of Population Health and Pathobiology, North Carolina State University, Raleigh, NC 27606, USA. Peter_Farin@ncsu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Breeding / methods
Cattle / embryology*
Embryo Culture Techniques / methods,  veterinary*
Embryo Transfer / veterinary
Embryonic Development*
Female
Fertilization in Vitro / veterinary*
Gene Expression Regulation, Developmental
Male
Nuclear Transfer Techniques*
Phenotype
Placenta / blood supply,  growth & development,  physiology*
Pregnancy
Pregnancy Complications / epidemiology,  veterinary
Pregnancy Outcome / veterinary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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