Document Detail


Error-related negativity and tic history in pediatric obsessive-compulsive disorder.
MedLine Citation:
PMID:  22917203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response, which is often increased in patients with obsessive-compulsive disorder (OCD). However, the relation of the ERN to comorbid tic disorders has not been examined in patients with OCD. This study compared ERN amplitudes in patients with tic-related OCD, patients with non-tic-related OCD, and healthy controls.
METHOD: The ERN, correct response negativity, and error number were measured during an Eriksen flanker task to assess performance monitoring in 44 youth with a lifetime diagnosis of OCD and 44 matched healthy controls ranging in age from 10 to 19 years. Nine youth with OCD had a lifetime history of tics.
RESULTS: ERN amplitude was significantly increased in patients with OCD compared with healthy controls. ERN amplitude was significantly larger in patients with non-tic-related OCD than in patients with tic-related OCD or controls. ERN amplitude had a significant negative correlation with age in healthy controls but not in patients with OCD. Instead, in patients with non-tic-related OCD, ERN amplitude had a significant positive correlation with age at onset of OCD symptoms. ERN amplitude in patients was unrelated to OCD symptom severity, current diagnostic status, or treatment effects.
CONCLUSIONS: The results provide further evidence of increased error-related brain activity in pediatric OCD. The difference in the ERN between patients with tic-related and those with non-tic-related OCD provides preliminary evidence of a neurobiological difference between these two OCD subtypes. The results indicate the ERN is a trait-like measurement that may serve as a biomarker for non-tic-related OCD.
Authors:
Gregory L Hanna; Melisa Carrasco; Shannon M Harbin; Jenna K Nienhuis; Christina E LaRosa; Poyu Chen; Kate D Fitzgerald; William J Gehring
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-25
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  51     ISSN:  1527-5418     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2013-01-16     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  902-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
Affiliation:
University of Michigan, USA. ghanna@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age of Onset
Anxiety Disorders / diagnosis,  physiopathology,  psychology
Attention / physiology
Brain / physiopathology*
Brain Mapping
Cerebral Cortex / physiopathology
Child
Comorbidity
Conflict (Psychology)*
Contingent Negative Variation / physiology*
Decision Making / physiology*
Electroencephalography
Female
Frontal Lobe / physiopathology
Humans
Male
Nerve Net / physiopathology
Neuropsychological Tests*
Obsessive-Compulsive Disorder / diagnosis,  physiopathology*,  psychology
Orientation / physiology*
Pattern Recognition, Visual / physiology*
Reaction Time / physiology
Reference Values
Signal Processing, Computer-Assisted
Tic Disorders / diagnosis,  physiopathology*,  psychology
Young Adult
Grant Support
ID/Acronym/Agency:
F31 MH086273/MH/NIMH NIH HHS; K23 MH 082176/MH/NIMH NIH HHS; R01 MH085321/MH/NIMH NIH HHS; R01 MH086321/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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