Document Detail

Error filtration, interference, and the human linkage map.
MedLine Citation:
PMID:  1862077     Owner:  NLM     Status:  MEDLINE    
Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.
D C Shields; A Collins; K H Buetow; N E Morton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  88     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-04     Completed Date:  1991-09-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6501-5     Citation Subset:  IM    
Department of Community Medicine, University of Southampton, Southampton General Hospital, United Kingdom.
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MeSH Terms
Chromosome Mapping*
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 10*
Computer Simulation
Genome, Human*
Linkage (Genetics)*
Models, Genetic*
Monte Carlo Method

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