Document Detail


Error effects in anterior cingulate cortex reverse when error likelihood is high.
MedLine Citation:
PMID:  20203206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strong error-related activity in medial prefrontal cortex (mPFC) has been shown repeatedly with neuroimaging and event-related potential studies for the last several decades. Multiple theories have been proposed to account for error effects, including comparator models and conflict detection models, but the neural mechanisms that generate error signals remain in dispute. Typical studies use relatively low error rates, confounding the expectedness and the desirability of an error. Here we show with a gambling task and functional magnetic resonance imaging that when losses are more frequent than wins, the mPFC error effect disappears, and moreover, exhibits the opposite pattern by responding more strongly to unexpected wins than losses. These findings provide perspective on recent ERP studies and suggest that mPFC error effects result from a comparison between actual and expected outcomes.
Authors:
Ryan K Jessup; Jerome R Busemeyer; Joshua W Brown
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-05-05     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3467-72     Citation Subset:  IM    
Affiliation:
Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain Mapping
Cognition / physiology*
Decision Making / physiology*
Discrimination (Psychology) / physiology*
Executive Function / physiology
Female
Functional Laterality / physiology
Gyrus Cinguli / anatomy & histology,  physiology*
Humans
Judgment / physiology*
Magnetic Resonance Imaging
Male
Mental Processes / physiology
Neuropsychological Tests
Prefrontal Cortex / anatomy & histology,  physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
MH068346/MH/NIMH NIH HHS; R01 DA014119/DA/NIDA NIH HHS; R01 DA014119/DA/NIDA NIH HHS; R01 DA014119-08/DA/NIDA NIH HHS; R01 DA026457/DA/NIDA NIH HHS; R01 DA026457-01A1/DA/NIDA NIH HHS; R01 MH068346/MH/NIMH NIH HHS; R01 MH068346-03/MH/NIMH NIH HHS; R03 DA023462-01/DA/NIDA NIH HHS; R03 DA023462-01/DA/NIDA NIH HHS
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