Document Detail

Erosion-inhibiting potential of a stannous chloride-containing fluoride solution under acid flow conditions in vitro.
MedLine Citation:
PMID:  20627197     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study aimed to analyse the erosion-inhibiting potential of a single application of stannous chloride-containing fluoride solution on pellicle-covered enamel and dentine under constant acid flow conditions in vitro.
DESIGN: Bovine enamel (n=60) and dentine (n=60) samples were exposed 1h to the oral cavity of 4 healthy volunteers to allow for in situ pellicle formation. Pellicle-covered samples were randomly assigned to three groups (each n=20 enamel and n=20 dentine samples; 5 enamel and 5 dentine samples/volunteer) and treated once with a SnCl2/AmF/NaF (800 ppm Sn(II), 500 ppm F, pH 4.5) or a NaF solution (500 ppm F, pH 4.5) for 2 min or remained untreated (controls). Samples were eroded with hydrochloric acid (pH 2.6) in a small erosion chamber at 60 microl/min for 25 min. Calcium release into the acid was monitored in consecutive 30s intervals for 5 min, then at 1 min intervals up to a total erosion time of 25 min using the Arsenazo III procedure. Data were statistically analysed by random-effects linear models (p<0.05).
RESULTS: The stannous chloride-containing fluoride solution reduced calcium loss of enamel and dentine to up to 6 min and 3.5 min, respectively. Calcium loss (% of control) amounted from 24+/-7 (30s) up to 93+/-14 (6 min) in enamel and from 38+/-13 (30s) to 87+/-15 (3.5 min) in dentine. The sodium fluoride solution was unable to reduce enamel and dentine erosion at any time point.
CONCLUSION: A single application of a stannous chloride-containing fluoride solution reduced enamel and dentine erosion up to 6 min and 3.5 min of constant acid flow, respectively.
Hao Yu; Florian Just Wegehaupt; Markus Zaruba; Klaus Becker; Malgorzata Roos; Thomas Attin; Annette Wiegand
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-07-11
Journal Detail:
Title:  Archives of oral biology     Volume:  55     ISSN:  1879-1506     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-11     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  702-5     Citation Subset:  D; IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, 8032 Zurich, Switzerland.
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MeSH Terms
Calcium / analysis
Dental Enamel / drug effects,  metabolism,  pathology
Dental Pellicle / physiology
Dentin / drug effects,  metabolism,  pathology
Diamines / therapeutic use*
Fluorides / therapeutic use*
Fluorides, Topical / therapeutic use*
Hydrogen-Ion Concentration
Linear Models
Sodium Fluoride / therapeutic use
Tin Compounds / therapeutic use*
Tin Fluorides / therapeutic use
Tooth Erosion / prevention & control*
Reg. No./Substance:
0/Diamines; 0/Fluorides; 0/Fluorides, Topical; 0/Olaflur; 0/Tin Compounds; 0/Tin Fluorides; 0/amine fluoride solution; 7440-70-2/Calcium; 7681-49-4/Sodium Fluoride; 7772-99-8/stannous chloride

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