| The Erlangen Fitness Osteoporosis Prevention Study: a controlled exercise trial in early postmenopausal women with low bone density-first-year results. | |
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MedLine Citation:
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PMID: 12736880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effect of a 2-year vigorous, combined high-impact, strength, and endurance training program on bone mineral density (BMD) determined by dual-energy x-ray absorptiometry (DXA), quantitative computed tomography (QCT), and ultrasound in early postmenopausal women with osteopenia. DESIGN: Nonrandomized controlled trial, reporting 1-year data. SETTING: Community. PARTICIPANTS: Early postmenopausal (1-8y postmenopausal) osteopenic women (DXA T score at lumbar spine or total hip between -1 and -2.5 standard deviations). The exercise group (n=59; mean age, 55.1+/-3.4y) and control group (n=41; mean age, 55.9+/-3.1y) were recruited from community registers. INTERVENTION: Fourteen months of exercise training, with 2 joint sessions and 2 additional home training sessions. Exercise and control groups were supplemented individually with calcium and cholecalciferol up to 1500mg of calcium and 500IU of vitamin D per day. MAIN OUTCOMES MEASURES: BMD at the lumbar spine and total hip measured by DXA, isometric maximum strength, and maximal oxygen consumption (VO2max) during a stepwise running test to exhaustion. RESULTS: Bone density increased significantly at the lumbar spine for the exercise group (1.3%, P<.001) and decreased in the control group (-1.2%, P<.01). Differences at the total hip (-0.3%, not significant vs -0.8%, P<.05) and the femoral neck (-0.8%, P<.05 vs -1.8%, P<.001) were nonsignificant. Changes in isometric maximum strength were significant for each region (grip strength, trunk flexors and extensors, hip flexors, leg adductors and abductors, arm flexors and extensors) in the exercise group (11%-39%) compared with nonrelevant changes (-1.1% to 3.9%) in the control group. Between-group differences were significant (P<.01-.001) for all strength parameters. VO2max increased significantly by 11% (P<.001) in the exercise group but decreased in the control group by 4% (P<.05) while showing significant between-group differences. CONCLUSION: High-intensity exercise training can have a positive influence on bone density in early postmenopausal osteopenic women. |
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Authors:
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Wolfgang Kemmler; Klaus Engelke; Jürgen Weineck; Johannes Hensen; Willi A Kalender |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 84 ISSN: 0003-9993 ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-08 Completed Date: 2003-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 673-82 Citation Subset: AIM; IM |
Affiliation:
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Institute of Medical Physics, University of Erlangen, Germany. wolfgang.kemmler@imp.uni.erlangen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Age Factors Anthropometry Bone Density Exercise Therapy / methods* Female Hand Strength Humans Isometric Contraction Middle Aged Nutrition Assessment Osteoporosis, Postmenopausal / diagnosis, etiology, prevention & control* Oxygen Consumption Physical Fitness* Postmenopause Questionnaires Severity of Illness Index Tomography, X-Ray Computed Treatment Outcome Weight Lifting |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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