Document Detail

Erionite bodies and fibres in bronchoalveolar lavage fluid (BALF) of residents from Tuzköy, Cappadocia, Turkey.
MedLine Citation:
PMID:  11245743     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The high incidence of malignant mesothelioma in some villages of Cappadocia (Turkey) is due to environmental exposure to erionite fibres. The aim was to evaluate the fibre burden in bronchoalveolar lavage fluid (BALF) from inhabitants of an erionite village and compare it with Turkish subjects with or without environmental exposure to tremolite asbestos. METHODS: Ferruginous bodies (FBs) and fibres were measured and analyzed by light and transmission electron microscopy (TEM) in the BALF of 16 subjects originating from Tuzköy. RESULTS: FBs were detected in the BALF of 12 subjects, with concentrations above 1 FB/ml in seven of them. Erionite was the central fibre of 95.7% of FBs. Erionite fibres were found in the BALF of all subjects, by TEM, and these fibres were low in Mg, K, and Ca compared with erionite from Tuzköy soil. The mean concentration of erionite fibres in BALF was similar to that of tremolite fibres in Turks with environmental exposure to tremolite. The proportion of fibres longer than 8 microm in BALF represented 35.6% for erionite compared with 14.0% for tremolite. The asbestos fibre concentrations in erionite villagers was not different from that in Turks without environmental exposure to tremolite. CONCLUSION: Analysis of BALF gives information about fibre retention in populations environmentally exposed to erionite for whom data on fibre burden from lung tissue samples are scarce. This may apply to exposed Turks having emigrated to other countries.
P Dumortier; L Coplü; I Broucke; S Emri; T Selcuk; V de Maertelaer; P De Vuyst; I Baris
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  58     ISSN:  1351-0711     ISO Abbreviation:  Occup Environ Med     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-03-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Chest Department, Hôpital Erasme, Université Libre de Bruxelles, Route de Lennik 808, B1070 Brussels, Belgium.
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MeSH Terms
Asbestos, Amphibole
Body Burden
Bronchoalveolar Lavage Fluid / chemistry*
Case-Control Studies
Environmental Exposure*
Mesothelioma / etiology*
Microscopy, Electron
Middle Aged
Mineral Fibers
Peritoneal Neoplasms / etiology
Pleural Neoplasms / etiology*
Soil Pollutants / analysis
Zeolites / analysis*
Reg. No./Substance:
0/Asbestos, Amphibole; 0/Mineral Fibers; 0/Soil Pollutants; 12510-42-8/erionite; 1318-02-1/Zeolites; 14567-73-8/tremolite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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