Document Detail

Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.
MedLine Citation:
PMID:  22465804     Owner:  NLM     Status:  Publisher    
Eriodictyol-7-O-glucoside, a flavonoid isolated from Dracocephalum rupestre, is among the most potent free radical scavenger. In the present study, we identified eriodictyol-7-O-glucoside as a novel nuclear factor E2-related factor 2 (Nrf2) activator using a high-throughput cellular screening method. This compound activated Nrf2 signaling pathway and was able to stabilize Nrf2 by delaying Nrf2 degradation, resulting in accumulation of Nrf2 protein and activation of the Nrf2-dependent protective response. Recent studies have suggested that activation of Nrf2 pathway would confer protection against cisplatin-induced toxicity. The protective role of eriodictyol-7-O-glucoside in cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC. Cotreatment of HRMC cells with eriodictyol-7-O-glucoside significantly improved cell survival under cisplatin exposure. These findings demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to subvert the side effects of cisplatin in normal cells.
Qingwen Hu; Donna D Zhang; Limei Wang; Hongxiang Lou; Dongmei Ren
Related Documents :
756954 - Improved growth of thermus aquaticus on cellular lysates.
8769954 - Vitamin d receptor and growth inhibition by 1,25-dihydroxyvitamin d3 in human malignant...
12632384 - Cell proliferation and differentiation during fracture healing are influenced by locall...
2833454 - Differential expression of platelet-derived growth factor and transforming growth facto...
6182814 - Basophil histamine release and humoral changes during immunotherapy. dissociation betwe...
23828214 - Cetuximab promotes anticancer drug toxicity in rhabdomyosarcomas with egfr amplificatio...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: ...
Next Document:  Power-efficient simulation of detailed cortical microcircuits on SpiNNaker.