| Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. | |
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MedLine Citation:
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PMID: 23202588 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The exoRNase Eri1 inhibits RNA interference and trims the 5.8S rRNA 3' end. It also binds to the stem-loop of histone mRNAs, but the functional importance of this interaction remains elusive. Histone mRNAs are normally degraded at the end of S phase or after pharmacological inhibition of replication. Both processes are impaired in Eri1-deficient mouse cells, which instead accumulate oligouridylated histone mRNAs. Eri1 trims the mature histone mRNAs by two unpaired nucleotides at the 3' end but stalls close to the double-stranded stem. Upon oligouridylation of the histone mRNA, the Lsm1-7 heteroheptamer recognizes the oligo(U) tail and interacts with Eri1, whose catalytic activity is then able to degrade the stem-loop in a stepwise manner. These data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure. |
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Authors:
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Kai P Hoefig; Nicola Rath; Gitta A Heinz; Christine Wolf; Jasmin Dameris; Aloys Schepers; Elisabeth Kremmer; K Mark Ansel; Vigo Heissmeyer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-02 |
Journal Detail:
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Title: Nature structural & molecular biology Volume: - ISSN: 1545-9985 ISO Abbreviation: Nat. Struct. Mol. Biol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186374 Medline TA: Nat Struct Mol Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Molecular Immunology, Helmholtz Zentrum München, München, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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