| Ergotamine-derived dopamine agonists and left ventricular function in Parkinson patients: systolic and diastolic function studied by conventional echocardiography, tissue Doppler imaging, and two-dimensional speckle tracking. | |
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MedLine Citation:
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PMID: 18490274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Ergot-derived dopamine agonists (EDDA) induce fibrotic heart valve disease. We aimed to investigate whether EDDA treatment also affects left ventricular (LV) function. METHODS AND RESULTS: Myocardial function was evaluated in 110 Parkinson patients [mean age (63.4 +/- 9.0 years)] treated for at least 6 months with either EDDA (n = 71) or non-EDDA (n = 39). LV ejection fraction did not differ between EDDA and non-EDDA patients [63 +/- 4% vs. 65 +/- 4% (ns)]. There was no difference in prevalence of diastolic dysfunction between EDDA and non-EDDA patients [7% vs. 8% (ns)]. Finally, averaged LV systolic myocardial strain and longitudinal displacement analysed by means of two-dimensional speckle tracking showed no difference between EDDA and non-EDDA patients [strain: 19 +/- 3% vs. 19 +/- 2% (ns) and longitudinal displacement: 12 +/- 2 mm vs. 12 +/- 2 mm (ns)]. Elevated p-NT-proBNP was found in 38% of EDDA patients and in 59% of non-EDDA patients (ns). CONCLUSION: In contrast to the well-established association between EDDA treatment and valvular fibrosis, EDDA did not have a detectable adverse impact on myocardial systolic and diastolic function. |
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Authors:
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Vibeke Guldbrand Rasmussen; Steen Hvitfeldt Poulsen; Erik Dupont; Karen Ostergaard; Gholamhossein Safikhany; Henrik Egeblad |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-07 |
Journal Detail:
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Title: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology Volume: 9 ISSN: 1532-2114 ISO Abbreviation: Eur J Echocardiogr Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-24 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890618 Medline TA: Eur J Echocardiogr Country: England |
Other Details:
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Languages: eng Pagination: 803-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Biological Markers / blood Diastole Dopamine Agonists / adverse effects*, therapeutic use Echocardiography / methods* Echocardiography, Doppler, Pulsed Ergotamine / adverse effects*, therapeutic use Female Heart Valve Diseases / ultrasonography Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Multivariate Analysis Natriuretic Peptide, Brain / blood Parkinson Disease / blood, drug therapy, ultrasonography* Retrospective Studies Systole Ventricular Dysfunction, Left / ultrasonography Ventricular Function, Left* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dopamine Agonists; 113-15-5/Ergotamine; 114471-18-0/Natriuretic Peptide, Brain |
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