Document Detail

Ergometrine-induced arterial dilatation: an endothelium-mediated effect.
MedLine Citation:
PMID:  6737485     Owner:  NLM     Status:  MEDLINE    
Ergometrine has generally been regarded as a vasoconstrictor and is used clinically to provoke coronary vasospasm in susceptible patients [3, 8, 9]. The ergometrine response appears however to be complex in that it can be biphasic, the constrictor response being preceded by an initial dilator response in experimental models [4]. The explanation for this is unknown, as is the underlying mechanism responsible for the clinical condition of coronary vasospasm. We have investigated this biphasic response in isolated artery preparations and shown that the dilator component is due to ergometrine-induced release of endothelium-derived relaxant factor (EDRF).
T M Griffith; D H Edwards; M J Lewis; A H Henderson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  16     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-08-22     Completed Date:  1984-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-82     Citation Subset:  IM    
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MeSH Terms
Aorta, Thoracic / drug effects*,  physiology
Endothelium / physiology
Ergonovine / pharmacology*
Muscle Relaxation
Muscle, Smooth, Vascular / physiology
Vasodilation / drug effects*
Reg. No./Substance:

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