| Ergometrine-induced arterial dilatation: an endothelium-mediated effect. | |
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MedLine Citation:
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PMID: 6737485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ergometrine has generally been regarded as a vasoconstrictor and is used clinically to provoke coronary vasospasm in susceptible patients [3, 8, 9]. The ergometrine response appears however to be complex in that it can be biphasic, the constrictor response being preceded by an initial dilator response in experimental models [4]. The explanation for this is unknown, as is the underlying mechanism responsible for the clinical condition of coronary vasospasm. We have investigated this biphasic response in isolated artery preparations and shown that the dilator component is due to ergometrine-induced release of endothelium-derived relaxant factor (EDRF). |
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Authors:
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T M Griffith; D H Edwards; M J Lewis; A H Henderson |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 16 ISSN: 0022-2828 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-08-22 Completed Date: 1984-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 479-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / drug effects*, physiology Endothelium / physiology Ergonovine / pharmacology* Muscle Relaxation Muscle, Smooth, Vascular / physiology Rabbits Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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60-79-7/Ergonovine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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