| Ergogenic and antioxidant effects of spirulina supplementation in humans. | |
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MedLine Citation:
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PMID: 20010119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Spirulina is a popular nutritional supplement that is accompanied by claiMSS for antioxidant and performance-enhancing effects. Therefore, the aim of the present study was to examine the effect of spirulina supplementation on (i) exercise performance, (ii) substrate metabolism, and (iii) blood redox status both at rest and after exercise. METHODS: Nine moderately trained males took part in a double-blind, placebo-controlled, counterbalanced crossover study. Each subject received either spirulina (6 g x d(-1)) or placebo for 4 wk. Each subject ran on a treadmill at an intensity corresponding to 70%-75% of their VO2max for 2 h and then at 95% VO2max to exhaustion. Exercise performance and respiratory quotient during exercise were measured after both placebo and spirulina supplementation. Blood samples were drawn before, immediately after, and at 1, 24, and 48 h after exercise. Reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG, thiobarbituric acid-reactive substances (TBARS), protein carbonyls, catalase activity, and total antioxidant capacity (TAC) were determined. RESULTS: Time to fatigue after the 2-h run was significantly longer after spirulina supplementation (2.05 +/- 0.68 vs 2.70 +/- 0.79 min). Ingestion of spirulina significantly decreased carbohydrate oxidation rate by 10.3% and increased fat oxidation rate by 10.9% during the 2-h run compared with the placebo trial. GSH levels were higher after the spirulina supplementation compared with placebo at rest and 24 h after exercise. TBARS levels increased after exercise after placebo but not after spirulina supplementation. Protein carbonyls, catalase, and TAC levels increased similarly immediately after and 1 h after exercise in both groups. CONCLUSIONS: Spirulina supplementation induced a significant increase in exercise performance, fat oxidation, and GSH concentration and attenuated the exercise-induced increase in lipid peroxidation. |
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Authors:
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Maria Kalafati; Athanasios Z Jamurtas; Michalis G Nikolaidis; Vassilis Paschalis; Anastasios A Theodorou; Giorgos K Sakellariou; Yiannis Koutedakis; Dimitris Kouretas |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 42 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 142-51 Citation Subset: IM; S |
Affiliation:
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Institute of Human Performance and Rehabilitation, Center for Research and Technology - Thessaly, Trikala, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antioxidants / metabolism, pharmacology* Catalase / metabolism Cross-Over Studies Dietary Carbohydrates / metabolism Dietary Fats / metabolism Double-Blind Method Fatigue / physiopathology Glutathione / metabolism Humans Lipid Peroxidation / drug effects Male Oxygen Consumption / drug effects Placebos Protein Carbonylation / drug effects Running / physiology* Spirulina* Thiobarbituric Acid Reactive Substances / metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Placebos; 0/Thiobarbituric Acid Reactive Substances; 70-18-8/Glutathione; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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