Document Detail

Erectile dysfunction predicts generalised cardiovascular disease: evidence from a case-control study.
MedLine Citation:
PMID:  16989839     Owner:  NLM     Status:  MEDLINE    
AIMS: To determine whether idiopathic erectile dysfunction, in the absence of overt cardiovascular disease or cardiovascular risk factors, is associated with vascular or autonomic dysfunction. METHODS: We studied 49 men with ED (without known cardiovascular risk factors or disease) and 50 age-matched controls, aged 40-70 years. Macrovascular endothelial function was examined by brachial artery ultrasonography and microvascular function by venous occlusion plethysmography. Blood pressure measurement and electrocardiography were performed lying and standing, and the 30:15 RR ratio calculated. RESULTS: Body mass index, testosterone, fasting lipids and glucose did not differ significantly between groups. Standing pulse pressure was higher (50+/-1mm Hg versus 43+/-2mm Hg, p<0.004) and 30:15 RR ratio lower (0.97+/-0.01 versus 1.01+/-0.01, p<0.02) in the ED group. Flow-mediated dilatation of the brachial artery was not significantly different between groups. Flow debt repayment during forearm reactive hyperaemia was lower in the ED group (7.2+/-0.7 ml versus 9.5+/-0.8 ml per 100ml, p<0.02) than in controls. CONCLUSIONS: Men with idiopathic ED have evidence of endothelial dysfunction in forearm resistance vessels, increased pulse pressure and impaired heart rate variability. This supports the concept that erectile dysfunction is a predictor of cardiovascular dysfunction and a precursor of clinical cardiovascular disease.
Bronwyn G A Stuckey; John P Walsh; Helena L Ching; Alexander W Stuckey; Neil R Palmer; Peter L Thompson; Gerald F Watts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-20
Journal Detail:
Title:  Atherosclerosis     Volume:  194     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  458-64     Citation Subset:  IM    
Keogh Institute for Medical Research, Nedlands, WA, Australia.
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MeSH Terms
Autonomic Nervous System / physiopathology
Blood Pressure
Brachial Artery / pathology*,  ultrasonography
Cardiovascular Diseases / complications*
Carotid Arteries / pathology*,  ultrasonography
Case-Control Studies
Endothelium, Vascular / physiopathology
Erectile Dysfunction / complications*
Forearm / blood supply*
Heart Rate
Middle Aged
Regional Blood Flow
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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