| Erectile dysfunction predicts generalised cardiovascular disease: evidence from a case-control study. | |
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MedLine Citation:
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PMID: 16989839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To determine whether idiopathic erectile dysfunction, in the absence of overt cardiovascular disease or cardiovascular risk factors, is associated with vascular or autonomic dysfunction. METHODS: We studied 49 men with ED (without known cardiovascular risk factors or disease) and 50 age-matched controls, aged 40-70 years. Macrovascular endothelial function was examined by brachial artery ultrasonography and microvascular function by venous occlusion plethysmography. Blood pressure measurement and electrocardiography were performed lying and standing, and the 30:15 RR ratio calculated. RESULTS: Body mass index, testosterone, fasting lipids and glucose did not differ significantly between groups. Standing pulse pressure was higher (50+/-1mm Hg versus 43+/-2mm Hg, p<0.004) and 30:15 RR ratio lower (0.97+/-0.01 versus 1.01+/-0.01, p<0.02) in the ED group. Flow-mediated dilatation of the brachial artery was not significantly different between groups. Flow debt repayment during forearm reactive hyperaemia was lower in the ED group (7.2+/-0.7 ml versus 9.5+/-0.8 ml per 100ml, p<0.02) than in controls. CONCLUSIONS: Men with idiopathic ED have evidence of endothelial dysfunction in forearm resistance vessels, increased pulse pressure and impaired heart rate variability. This supports the concept that erectile dysfunction is a predictor of cardiovascular dysfunction and a precursor of clinical cardiovascular disease. |
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Authors:
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Bronwyn G A Stuckey; John P Walsh; Helena L Ching; Alexander W Stuckey; Neil R Palmer; Peter L Thompson; Gerald F Watts |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-20 |
Journal Detail:
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Title: Atherosclerosis Volume: 194 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-23 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 458-64 Citation Subset: IM |
Affiliation:
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Keogh Institute for Medical Research, Nedlands, WA, Australia. bstuckey@cyllene.uwa.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Autonomic Nervous System / physiopathology Blood Pressure Brachial Artery / pathology*, ultrasonography Cardiovascular Diseases / complications* Carotid Arteries / pathology*, ultrasonography Case-Control Studies Endothelium, Vascular / physiopathology Erectile Dysfunction / complications* Forearm / blood supply* Heart Rate Humans Male Middle Aged Plethysmography Regional Blood Flow Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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