Document Detail

Erectile dysfunction in systemic sclerosis.
MedLine Citation:
PMID:  19525406     Owner:  NLM     Status:  MEDLINE    
Erectile dysfunction (ED) is observed in up to 81% of men with systemic sclerosis (SSc) and therefore should be counselled as a common complaint in this disorder. Whereas ED is frequently associated with atherosclerosis in the general population in which it is also a harbinger of cardiovascular events, ED has a different aetiology in SSc. In SSc the penile blood flow is impaired due to both myointimal proliferation of small arteries and corporal fibrosis. Data on the prevention of ED in SSc are not available. On-demand phosphodiesterase type 5 (PDE-5) inhibitors are not effective in improving erectile function, but fixed daily or alternate day regimens of long acting PDE-5 inhibitors provide a measurable, although often limited, clinical benefit. When intracavernous injections of prostaglandin E1 (alprostadil) are ineffective, the implantation of a penile prosthesis may be considered. Complex treatment options may require the involvement of urology.
U A Walker; A Tyndall; R Ruszat
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  68     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1083-5     Citation Subset:  IM    
Department of Rheumatology, Basel University, Basel, Switzerland.
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MeSH Terms
Erectile Dysfunction / etiology*,  physiopathology,  therapy
Penile Erection / physiology
Penile Prosthesis
Phosphodiesterase Inhibitors / therapeutic use
Scleroderma, Systemic / complications*,  physiopathology
Reg. No./Substance:
0/Phosphodiesterase Inhibitors

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