| Erectile dysfunction can improve the effectiveness of the current guidelines for the screening for asymptomatic coronary artery disease in diabetes. | |
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MedLine Citation:
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PMID: 21861245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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About 40% of diabetic patients with asymptomatic coronary artery disease (CAD) are missed on the basis of the current screening guidelines. Erectile Dysfunction (ED) is a powerful marker of asymptomatic CAD. Aim of the study is to evaluate whether ED can improve the effectiveness of the current guidelines for the screening of CAD in diabetes. From among 299 consecutive men with newly diagnosed type 2 diabetes without any apparent vascular complication, 293 (mean age 56.6±5.9 years) were enrolled. Among them, 219 did not have myocardial ischemia (NO CAD group) and 74 men had a coronary stenosis angiographically proven (CAD group). Five risk factors (RFs) of the current screening guidelines (hypertension, dyslipidemia, family history for CAD, smoking e micro/macroalbuminuria) and ED were assessed. ED was significantly more prevalent in the CAD than in the NO CAD group (37.8 versus 15.1%; P<0.001) and was a predictor of asymptomatic CAD (OR: 4.4; 95%CI: 2.1-9.0; P<0.001). If ED is added to the list of RFs, it can increase the sensitivity of the current guidelines from 62 to 89%, without a significant variation in specificity (from 60 to 57%). The negative predictive value can increase from 82 to 94%. ED can reduce from 37.84 to 10.81% the percentage of patients with silent CAD missed at the screening. This study first shows that ED can improve the effectiveness in discriminating diabetic men to screen for asymptomatic CAD, when it is added to the list of RFs of the current screening guidelines. |
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Authors:
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Carmine Gazzaruso; Adriana Coppola; Tiziana Montalcini; Cinzia Valenti; Adriana Garzaniti; Gabriele Pelissero; Fabrizio Salvucci; Pietro Gallotti; Arturo Pujia; Colomba Falcone; Sebastiano B Solerte; Andrea Giustina |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2011-08-23 |
Journal Detail:
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Title: Endocrine Volume: 40 ISSN: 1559-0100 ISO Abbreviation: Endocrine Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-30 Completed Date: 2012-02-23 Revised Date: 2012-03-15 |
Medline Journal Info:
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Nlm Unique ID: 9434444 Medline TA: Endocrine Country: United States |
Other Details:
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Languages: eng Pagination: 273-9 Citation Subset: IM |
Affiliation:
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Internal Medicine, Diabetes, Endocrine-Metabolic Diseases and Cardiovascular Prevention Unit and the Centre for Applied Clinical Research (Ce.R.C.A.), Clinical Institute Beato Matteo, Corso Pavia 84, Vigevano, 27029, Pavia, Italy. c.gazzaruso@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Coronary Angiography Coronary Artery Disease / complications, diagnosis*, physiopathology Coronary Stenosis / complications, diagnosis, physiopathology, radiography Diabetes Mellitus, Type 2 / complications* Diabetic Angiopathies / complications, diagnosis*, physiopathology Early Diagnosis Erectile Dysfunction / complications, epidemiology* Humans Italy / epidemiology Male Mass Screening Middle Aged Multivariate Analysis Practice Guidelines as Topic* Prevalence Questionnaires Risk Factors Severity of Illness Index |
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Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Comment In:
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Endocrine. 2011 Oct;40(2):149-50
[PMID:
21927890
]
J Urol. 2012 Mar;187(3):991-2 [PMID: 22325530 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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