Document Detail

Erectile dysfunction as a coronary artery disease risk equivalent.
MedLine Citation:
PMID:  18984455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The conditions that predispose patients to erectile dysfunction are substantially similar to the coronary artery disease risk factors, including diabetes mellitus, hypertension, hyperlipidemia, obesity, sedentary lifestyle, depression, age, and smoking. Because of these shared risks and overlapping pathophysiologic mechanisms, we designed this pilot study to address the hypothesis that the presence of coronary artery calcium, a known indicator of increased cardiac risk, is associated with erectile dysfunction. METHODS AND RESULTS: A prospective registry enrolled 9150 men who underwent multidetector computed tomography. Subjects supplied baseline data regarding demographic variables, coronary risk factors, and erectile dysfunction symptoms or lack thereof. The 2 groups then underwent computed tomography to screen for the presence or absence of coronary artery calcium. Subjects with erectile dysfunction were older, had higher triglyceride levels, had higher blood pressures, and were more likely to have measurable coronary artery calcification than men without erectile dysfunction (79% vs 58%, P < .001). CONCLUSION: Erectile dysfunction is significantly associated with abnormal coronary artery calcification and, like peripheral arterial disease, might warrant consideration as a coronary artery disease risk equivalent.
John H Lee; Raphael Ngengwe; Philip Jones; Fengming Tang; James H O'Keefe
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Publication Detail:
Type:  Journal Article     Date:  2008-09-12
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  15     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  800-3     Citation Subset:  IM    
Mid America Heart Institute, Kansas City, MO, USA.
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MeSH Terms
Blood Pressure
Calcium / metabolism
Coronary Artery Disease / complications,  diagnosis*
Erectile Dysfunction / complications,  diagnosis*
Middle Aged
Pilot Projects
Prospective Studies
Risk Factors
Tomography, X-Ray Computed / methods
Triglycerides / metabolism
Reg. No./Substance:
0/Triglycerides; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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