| Erectile dysfunction as a coronary artery disease risk equivalent. | |
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MedLine Citation:
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PMID: 18984455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The conditions that predispose patients to erectile dysfunction are substantially similar to the coronary artery disease risk factors, including diabetes mellitus, hypertension, hyperlipidemia, obesity, sedentary lifestyle, depression, age, and smoking. Because of these shared risks and overlapping pathophysiologic mechanisms, we designed this pilot study to address the hypothesis that the presence of coronary artery calcium, a known indicator of increased cardiac risk, is associated with erectile dysfunction. METHODS AND RESULTS: A prospective registry enrolled 9150 men who underwent multidetector computed tomography. Subjects supplied baseline data regarding demographic variables, coronary risk factors, and erectile dysfunction symptoms or lack thereof. The 2 groups then underwent computed tomography to screen for the presence or absence of coronary artery calcium. Subjects with erectile dysfunction were older, had higher triglyceride levels, had higher blood pressures, and were more likely to have measurable coronary artery calcification than men without erectile dysfunction (79% vs 58%, P < .001). CONCLUSION: Erectile dysfunction is significantly associated with abnormal coronary artery calcification and, like peripheral arterial disease, might warrant consideration as a coronary artery disease risk equivalent. |
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Authors:
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John H Lee; Raphael Ngengwe; Philip Jones; Fengming Tang; James H O'Keefe |
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Publication Detail:
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Type: Journal Article Date: 2008-09-12 |
Journal Detail:
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Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 15 ISSN: 1532-6551 ISO Abbreviation: J Nucl Cardiol Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-11-05 Completed Date: 2009-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 800-3 Citation Subset: IM |
Affiliation:
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Mid America Heart Institute, Kansas City, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Calcium / metabolism Coronary Artery Disease / complications, diagnosis* Erectile Dysfunction / complications, diagnosis* Humans Male Middle Aged Pilot Projects Prospective Studies Registries Risk Risk Factors Tomography, X-Ray Computed / methods Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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