Document Detail

ErbB4 (JM-b/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein.
MedLine Citation:
PMID:  16819515     Owner:  NLM     Status:  MEDLINE    
Human papillomavirus type 16 E5 (HPV-16 E5) is a highly hydrophobic membrane protein with weak-transforming activity, which is associated with ErbB4 receptor in HPV-16-infected cervical lesions. Presently, we investigated the transforming mechanisms of E5 involving ErbB4 signaling. Firstly, we report a role for ErbB4 (JM-b/CYT-1) receptor that activates c-jun gene expression and phosphorylating at Ser63 and Ser73 of the c-Jun protein in ligand-independent and Ras-c-jun NH(2)-terminal kinase-dependent pathway. Secondly, we show that HPV-16 E5 protein can form a complex with ErbB4 via binding to the extracellular and transmembrane domains of ErbB4 (JM-b/CYT-1). When co-expressing HPV-16 E5 and ErbB4 in cells, E5 can abrogate ErbB4-induced c-Jun protein expression and phosphorylation resulted in increasing cell proliferation compared to ErbB4-expressing cells. The interaction between of HPV-16 E5 and ErbB4 provides more insight into the mechanisms of HPV-16 E5 transformation induction.
S-L Chen; S-T Lin; T-C Tsai; W-C Hsiao; Y-P Tsao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-03
Journal Detail:
Title:  Oncogene     Volume:  26     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-04     Completed Date:  2007-02-26     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  42-53     Citation Subset:  IM    
Department of Microbiology, Gradurate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
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MeSH Terms
Base Sequence
Blotting, Western
Cell Line
DNA Primers
Microscopy, Fluorescence
Oncogene Proteins, Viral / physiology*
Proto-Oncogene Proteins c-jun / chemistry,  metabolism*
Receptor, Epidermal Growth Factor / physiology*
Reverse Transcriptase Polymerase Chain Reaction
Serine / metabolism
Reg. No./Substance:
0/DNA Primers; 0/Oncogene Proteins, Viral; 0/Proto-Oncogene Proteins c-jun; 0/oncogene protein E5, Human papillomavirus type 16; 56-45-1/Serine; EC, Epidermal Growth Factor; EC tyrosine-protein kinase erbB-4

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