Document Detail

Eradication therapy in Helicobacter pylori-positive patients with halitosis: long-term outcome.
MedLine Citation:
PMID:  17303947     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to investigate the incidence and long-term outcome of halitosis before and after eradication therapy in patients with functional dyspepsia and Helicobacter pylori infection. SUBJECTS AND METHODS: Halitosis and dyspepsia-related symptoms were investigated by way of a questionnaire. Only patients with functional dyspepsia, H. pylori infection and no histological evidence of atrophy were included in the study. A total of 18 patients fulfilled these criteria and completed the study. Four to six weeks after the end of eradication treatment, endoscopy or [(13)C] breath test was performed to check for H. pylori in the gastric mucosa. Halitosis and dyspeptic symptoms were re-evaluated during and at the end of follow-up. RESULTS: H. pylori infection was eradicated in all patients, in the 14/18 patients (77.8%) with triple drug therapy, and the 4/18 patients (22.2%) with quadruple drug therapy. During the follow-up period (mean 55.8 +/- 21.3 months (range 6-108 months)) resolution of halitosis was observed in 16/18 patients (88.9%), while 2 patients (11.1%) (p < 0.001) continued to present with halitosis. Also, eradication therapy resulted in statistically significant relief of all dyspeptic symptoms, except bloating. CONCLUSION: Eradication of H. pylori in patients with functional dyspepsia and halitosis results in sustained resolution of halitosis during long-term follow-up in the majority of cases. This finding supports the existence of a link between H. pylori infection and halitosis and suggests that H. pylori eradication might be considered in patients with halitosis.
Panagiotis Katsinelos; Kostas Tziomalos; Grigoris Chatzimavroudis; Themistoklis Vasiliadis; Taxiarchis Katsinelos; Ioannis Pilpilidis; Ioannis Triantafillidis; George Paroutoglou; Basilis Papaziogas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical principles and practice : international journal of the Kuwait University, Health Science Centre     Volume:  16     ISSN:  1011-7571     ISO Abbreviation:  Med Princ Pract     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8901334     Medline TA:  Med Princ Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Department of Endoscopy and Motility Unit, G. Gennimatas General Hospital, Thessaloniki, Greece.
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MeSH Terms
Amoxicillin / therapeutic use
Anti-Bacterial Agents / therapeutic use
Anti-Ulcer Agents / therapeutic use
Breath Tests
Clarithromycin / therapeutic use
Drug Therapy, Combination
Halitosis / epidemiology*,  microbiology,  prevention & control
Helicobacter Infections / drug therapy*
Helicobacter pylori*
Middle Aged
Omeprazole / therapeutic use
Statistics, Nonparametric
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 26787-78-0/Amoxicillin; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin

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