Document Detail

Eradication of aortic infections with the use of cryopreserved arterial homografts.
MedLine Citation:
PMID:  8783987     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The surgical treatment of vascular infection is associated with a substantial early and late mortality. Cryopreserved homografts were evaluated for in situ reconstruction in aortic infections. METHODS: Between January 1991 and July 1995, homografts were used in 19 patients (mean age, 61 +/- 13 years; range, 40-85 years) with mycotic aneurysms (9/19; 47%) or infected grafts (10/19; 53%) in the thoracic (7/19; 37%) or abdominal (12/19; 63%) aorta. Sepsis was present preoperatively in 14 of 19 (74%) patients, and 18 of 19 (95%) had received antibiotic treatment for 6.4 +/- 6 months (range, 1-36 months). Up to ten previous vascular procedures had been done in 11 of 19 patients (58%). RESULTS: There was one (5.2%) early and two (11%) late deaths, with one (5.5%) of the late deaths being homograft related. The mean hospital stay was 27 +/- 26 days (range, 7-84 days). Antibiotics were given postoperatively for 30 +/- 12 days (range, 4-84 days). During the follow-up period of 18.6 +/- 13 months (range, 7-60 months), there were no instances of reinfection, suture line rupture, homograft stenosis, or anastomotic aneurysms. CONCLUSIONS: Cryopreserved arterial homografts allow safe in situ reconstruction, decrease early and midterm mortality, and reduce antibiotic requirements. Early and midterm reoperations are unnecessary.
P R Vogt; L K von Segesser; Y Goffin; U Niederhäuser; M Genoni; A Künzli; M Lachat; M I Turina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  62     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-09     Completed Date:  1996-10-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  640-5     Citation Subset:  AIM; IM    
Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland.
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MeSH Terms
Aged, 80 and over
Aneurysm, Infected / surgery*
Antibiotic Prophylaxis
Aortic Aneurysm / surgery*
Aortic Diseases / surgery*
Arteries / transplantation*
Length of Stay
Middle Aged
Polyethylene Terephthalates
Postoperative Complications
Prosthesis-Related Infections / surgery*
Reg. No./Substance:
0/Polyethylene Terephthalates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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