Document Detail


Eradication of Syphacia muris from food-restricted rats without environmental decontamination.
MedLine Citation:
PMID:  15697194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rodent pinworms rarely cause clinical disease, but infestation can affect experimental results. Our facility maintained a colony of Wistar rats for behavioral pharmacology studies that had been infested with Syphacia muris for > 15 years. The laboratory in which the animals were housed encompassed several rooms and contained a variety of complex behavioral equipment, including > 60 operant chambers. Several prior attempts to eliminate the pinworms were unsuccessful because of inadequate duration of treatment and incomplete environmental decontamination. Many of the rats in this colony were food-restricted as part of behavioral studies. Pinworms were eliminated from these animals by treating them with 450 ppm fenbendazole-containing feed for 3 consecutive weeks followed by 6 weeks of alternating every other week with standard rodent diet. Rats not on food restriction protocols were treated on the same schedule with 150 ppm fenbendazole-containing feed. Environmental decontamination of eggs from the behavioral equipment was not attempted. One year after treatment, the colony has remained free of S. muris. We adapted previously published protocols to our situation, including the problem of food-restricted rats and unfeasible environmental decontamination, to eradicate S. muris from our colony.
Authors:
Shayne C Barlow; Melissa M Brown; Hugh V Price
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science     Volume:  44     ISSN:  1060-0558     ISO Abbreviation:  Contemp Top Lab Anim Sci     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204153     Medline TA:  Contemp Top Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-5     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animal Husbandry / methods
Animals
Animals, Laboratory*
Antinematodal Agents / therapeutic use
Decontamination* / methods
Diet
Dose-Response Relationship, Drug
Fenbendazole / therapeutic use
Food Deprivation*
Oxyuriasis / parasitology,  prevention & control,  veterinary*
Oxyuroidea / drug effects,  physiology
Rats
Rats, Sprague-Dawley
Rodent Diseases / parasitology,  prevention & control*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antinematodal Agents; 43210-67-9/Fenbendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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