| Eradication of Rickettsia tsutsugamushi from patients' blood by chemotherapy, as assessed by the polymerase chain reaction. | |
| | |
MedLine Citation:
|
PMID: 7741170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The presence of Rickettsia tsutsugamushi DNA in peripheral blood mononuclear cells of eight patients with tsutsugamushi disease was determined by the polymerase chain reaction during antibiotic treatment with minocycline or doxycycline. Rickettsia tsutsugamushi DNA was detectable in all samples from these patients collected the day before treatment began. After the initiation of chemotherapy, all samples tested positive on the third or fourth day, and one sample tested positive on the eighth day, showing a slow action of the drugs against the rickettsia within cells. Immune responses against R. tsutsugamushi also seemed to be important for eradication of the pathogens, as suggested by patients' high antibody titers. |
| | |
Authors:
|
K Murai; A Okayama; H Horinouchi; T Oshikawa; N Tachibana; H Tsubouchi |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of tropical medicine and hygiene Volume: 52 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-06-06 Completed Date: 1995-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 325-7 Citation Subset: AIM; IM |
Affiliation:
|
Second Department of Internal Medicine, Miyazaki Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Antibodies, Bacterial / blood Base Sequence DNA Primers / chemistry DNA, Bacterial / blood*, chemistry Doxycycline / therapeutic use Electrophoresis, Agar Gel Female Fluorescent Antibody Technique Humans Leukocytes, Mononuclear / microbiology* Male Middle Aged Minocycline / therapeutic use Molecular Sequence Data Orientia tsutsugamushi / genetics, immunology, isolation & purification* Polymerase Chain Reaction* Scrub Typhus / drug therapy, microbiology* |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Bacterial; 0/DNA Primers; 0/DNA, Bacterial; 10118-90-8/Minocycline; 564-25-0/Doxycycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term efficacy of primaquine in the treatment of vivax malaria in nonimmune travelers.
Next Document: Use of the rhesus monkey as an experimental model to test the degree of efficacy of an anti-sporozoi...