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Eradication of Methicillin-Resistant Staphylococcus aureus in Pressure Ulcers Comparing a Polyhexanide-Containing Cellulose Dressing with Polyhexanide Swabs in a Prospective Randomized Study.
MedLine Citation:
PMID:  22218066     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: The study evaluated eradication of methicillin-resistant Staphylococcus aureus (MRSA) from pressure ulcers comparing swabs containing polyhexanide with a cellulose dressing + polyhexanide. After receiving approval from the ethics committee and informed consent, patients from the centers were recruited. DESIGN:: Prospective randomized study. Thirty patients (n = 15/n = 15), not responding to wound disinfection after a washout period of 2 weeks, were included in the intention-to-treat analysis. SETTING:: This study was performed on hospital patients. PATIENTS:: Patients had pressure ulcers containing MRSA. INTERVENTIONS:: For the control group, cleansing was performed with polyhexanide swabs (20 minutes), after which a foam dressing was applied. The study group received a polyhexanide-containing cellulose dressing. For bacterial analysis, semiquantitative swab cultures (Robert Koch Institute recommendations) were taken on days 0, 7, and 14 and during 3 consecutive days. RESULTS:: The groups were comparable at baseline. At day 7, in the control group, 6 of 15 (40%) MRSA eradication. For the study group, there were 13 of 15 (86.67%) who showed MRSA eradication. At day 14, in the control group, there were 10 of 15 (66.67%) who had MRSA eradication, compared with the study group, where 15 of 15 (100%; P < .05) had the MRSA eradicated. CONCLUSIONS:: Wound disinfection with polyhexanide was shown to be successful in both groups, showing superior results for the study group.
Authors:
Thomas Wild; Maria Bruckner; Martina Payrich; Christoph Schwarz; Thomas Eberlein; Anneke Andriessen
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Advances in skin & wound care     Volume:  25     ISSN:  1538-8654     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100911021     Medline TA:  Adv Skin Wound Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  17-22     Citation Subset:  -    
Affiliation:
Thomas Wild, MD, is a surgeon specialized in wound care management, and Maria Bruckner, RN, is a nurse specialist in wound care management, Paracelsus Medical University, Salzburg, Austria. Martina Payrich, is a medical student, University Hospital for Surgery, Medical University, Vienna, Austria. Christoph Schwarz, MD, is a resident at the Department of General Surgery, Medical University, Vienna, Austria. Thomas Eberlein, MD, is medical director, Wound Competence Centre, Linz, Austria. Anneke Andriessen, PhD, is director, Andriessen Consultants, Malden, the Netherlands.
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