Document Detail

Eradication of Helicobacter pylori for the prevention of peptic ulcer rebleeding.
MedLine Citation:
PMID:  17669099     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the effect of Helicobacter pylori eradication on ulcer bleeding recurrence in a prospective, long-term study including more than 400 patients. METHODS: Patients with peptic ulcer bleeding were prospectively included. H. pylori infection was confirmed by rapid urease test, histology or (13)C-urea breath test. Several eradication regimens were used. Ranitidine 150 mg was administered daily until eradication was confirmed by breath test 8 weeks after completing eradication therapy. Patients with therapy failure received a second or third course of therapy. Patients with eradication success did not receive maintenance anti-ulcer therapy, and were controlled yearly with a repeated breath test. RESULTS: Four hundred and twenty-two patients were followed up for at least 12 months, with a total of 906 patient-years of follow up. Mean age was 59 years, and 35% were previous nonsteroidal anti-inflammatory drug (NSAID) users. Sixty-nine percent had duodenal, 24% gastric, and 7% pyloric ulcer. Recurrence of bleeding was demonstrated in two patients at 1 year (incidence: 0.22% per patient-year of follow up), which occurred after NSAID use in both cases. CONCLUSION: Peptic ulcer rebleeding does not occur in patients with complicated ulcers after H. pylori eradication. Maintenance anti-ulcer (antisecretory) therapy is not necessary if eradication is achieved.
Javier P Gisbert; Xavier Calvet; Faust Feu; Felipe Bory; Angel Cosme; Pedro Almela; Santos Santolaria; Rosario Aznárez; Manuel Castro; Nuria Fernández; Rafael García-Grávalos; Nuria Cañete; Adolfo Benages; Miguel Montoro; Fernando Borda; Angeles Pérez-Aisa; Jose María Piqué
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Helicobacter     Volume:  12     ISSN:  1083-4389     ISO Abbreviation:  Helicobacter     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605411     Medline TA:  Helicobacter     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-86     Citation Subset:  IM    
Department of Gastroenterology, Hospital de la Princesa, Madrid, Spain.
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MeSH Terms
Amoxicillin / therapeutic use
Clarithromycin / therapeutic use
Follow-Up Studies
Helicobacter Infections / drug therapy*
Helicobacter pylori / drug effects*
Middle Aged
Peptic Ulcer / complications,  drug therapy,  microbiology
Peptic Ulcer Hemorrhage / etiology,  microbiology,  prevention & control*
Prospective Studies
Time Factors
Treatment Outcome
Reg. No./Substance:
26787-78-0/Amoxicillin; 81103-11-9/Clarithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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