Document Detail

Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer's disease.
MedLine Citation:
PMID:  19240960     Owner:  NLM     Status:  MEDLINE    
Infectious agents have been proposed as potential causes of Alzheimer's disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cognitive Examination for the Elderly) and functional (FRSSD: Functional Rating Scale for Symptoms of Dementia) status parameters. In the first part of the study, a total of 50 consecutive patients with AD and 30 age-matched anaemic controls underwent an upper gastrointestinal endoscopy, and gastric mucosal biopsies were obtained to detect the presence of Hp infection by histologic analysis and rapid urease test. Serum anti-Hp-specific IgG level was analysed by enzyme-linked immunosorbent assay. In the second part, Hp-positive AD patients received a triple eradication regimen (omeprazole, clarithromycin and amoxicillin), and all patients were followed up for 2 years, while under the same treatment with cholinesterase inhibitors. Hp was detected in 88% of AD patients and in 46.7% of controls (P < 0.001). Hp eradication was successful in 84.8% of treated patients. At the 2-year clinical endpoint, cognitive and functional status parameters improved in the subgroup of patients where Hp eradication was successful (P < 0.001 and P = 0.049 for MMSE and CAMCOG, respectively; P < 0.001 for FRSSD), but not in the other patients. Hp eradication may positively influence AD manifestations, suggesting a possible common link between Hp and AD.
Jannis Kountouras; Marina Boziki; Emmanuel Gavalas; Christos Zavos; Nikolaos Grigoriadis; Georgia Deretzi; Dimitrios Tzilves; Panagiotis Katsinelos; Magda Tsolaki; Dimitrios Chatzopoulos; Ioannis Venizelos
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-02-25
Journal Detail:
Title:  Journal of neurology     Volume:  256     ISSN:  1432-1459     ISO Abbreviation:  J. Neurol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-19     Completed Date:  2009-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  758-67     Citation Subset:  IM    
Department of Gastroenterology, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / drug therapy*,  epidemiology*,  prevention & control
Amoxicillin / administration & dosage
Anti-Bacterial Agents / administration & dosage*
Anti-Ulcer Agents / administration & dosage
Clarithromycin / administration & dosage
Cognition Disorders / drug therapy,  microbiology,  prevention & control
Endpoint Determination
Gastric Mucosa / drug effects,  microbiology,  pathology
Helicobacter Infections / diagnosis,  drug therapy*,  epidemiology*
Helicobacter pylori / drug effects*
Middle Aged
Neuropsychological Tests
Omeprazole / administration & dosage
Treatment Outcome
Urease / analysis,  blood
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 26787-78-0/Amoxicillin; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin; EC

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