Document Detail

Equivocal notions of accuracy and genetic screening of the general population.
MedLine Citation:
PMID:  9615568     Owner:  NLM     Status:  MEDLINE    
The explosive growth in genetic technology quickly will make possible an unprecedented number of tests for genetically based conditions. A necessary condition for the use of such tests without risk of harm to the patient is their accuracy. However, most discussions of test accuracy in the literature have equivocated between two importantly different meanings of the word. In particular, it must be remembered that a high analytic accuracy does not imply a high diagnostic accuracy. Questions about the diagnostic accuracy of genetic tests presently loom large because of our limited knowledge of the complex etiology of disease and the distribution within the general population of the causal factors involved. Our current inability to supply patients with accurate diagnosis based on genetic information, however, is less problematic when examined in the context of new reproductive technologies such as in vitro fertilization and intraplasmic sperm injection.
K C Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Mount Sinai journal of medicine, New York     Volume:  65     ISSN:  0027-2507     ISO Abbreviation:  Mt. Sinai J. Med.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-07     Completed Date:  1998-08-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0241032     Medline TA:  Mt Sinai J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-84; discussion 215-23     Citation Subset:  E; IM    
Department of Philosophy and Religion, Clemson University, SC 29634-1508, USA.
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MeSH Terms
Attitude to Health
Cystic Fibrosis / genetics
Genetic Counseling
Genetic Techniques / standards
Genetic Testing*
Genetics, Population*
Preimplantation Diagnosis
Prenatal Diagnosis
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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