Document Detail

Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation.
MedLine Citation:
PMID:  22025568     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Ultraviolet (UV) corneal cross-linking is an accepted method for treating corneal ecstatic disorders. The authors evaluated whether a rapid treatment protocol (higher intensity and shorter irradiation time) could achieve the same increase in corneal stiffness as the currently used standard protocol.
METHODS: Stress-strain measurements were performed on porcine corneal strips. The corneas (n = 72) were cut into three strips, each randomly receiving a different treatment: rapid (10 mW/cm(2), 9 minutes), standard (3 mW/cm(2), 30 minutes), or no (control, 0 mW/cm(2)) irradiation. After irradiation, the Young's modulus of each strip was determined. The results of the stress-strain measurements were analyzed statistically.
RESULTS: Statistical analysis showed that, after irradiation, the median value of Young's modulus from both active treatment groups (rapid, 3.83 N/mm(2); standard, 3.88 N/mm(2)) was significantly higher (P < 0.05) than that of the control group (2.91 N/mm(2)). Treatment increased Young's modulus by a factor of 1.3. However, there was no significant difference (P = 0.43) between the rapid and standard groups in the median of Young's modulus.
CONCLUSIONS: Rapid UV cross-linking treatment can be regarded as equivalent to the standard procedure in terms of increase in corneal stiffness. The new rapid protocol shortens the treatment duration by more than two thirds, from 30 to 9 minutes. The safety of the higher intensities must be addressed in further clinical studies.
Silvia Schumacher; Lydia Oeftiger; Michael Mrochen
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Publication Detail:
Type:  Journal Article     Date:  2011-11-25
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-02-16     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9048-52     Citation Subset:  IM    
IROC AG, Institute of Refractive and Ophthalmic Surgery, Stockerstrasse 37, Zurich, Switzerland.
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MeSH Terms
Biomechanics / physiology
Collagen / metabolism*
Cornea / drug effects,  physiology*
Cross-Linking Reagents / pharmacology*
Elastic Modulus
Elasticity / physiology*
Photosensitizing Agents / pharmacology*
Riboflavin / pharmacology*
Ultraviolet Rays*
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Photosensitizing Agents; 83-88-5/Riboflavin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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