| Equithesin: a hibernation-inducing drug? | |
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MedLine Citation:
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PMID: 1360383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Hibernating insectivore species (hedgehogs) and non-hibernating rodents (guinea pig and rat) were anaesthetized with 'equithesin' (a mixture of chloral hydrate, magnesium sulphate, and pentobarbitone sodium). 2. The physiological responses shown by the hedgehogs were similar to those observed in hedgehogs during a natural or cold-induced hibernation. 3. These responses included a strong reduction in body temperature, heart rate, respiration and oxygen consumption, and brain activity. 4. Such responses to equithesin were not observed in the non-hibernating rodent species. 5. These results suggest that equithesin is a potential tool for hibernation research. |
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Authors:
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R Batzri-Izraeli; Z Wollberg; R Dmi'el |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Volume: 103 ISSN: 0742-8413 ISO Abbreviation: Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1993-01-07 Completed Date: 1993-01-07 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 8310013 Medline TA: Comp Biochem Physiol C Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 273-5 Citation Subset: IM |
Affiliation:
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Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics
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pharmacology* Animals Body Temperature Brain / physiology Chloral Hydrate / pharmacology* Drug Combinations Guinea Pigs Heart Rate / physiology Hedgehogs / physiology* Hibernation / drug effects, physiology* Magnesium Sulfate / pharmacology* Oxygen Consumption / drug effects Pentobarbital / pharmacology* Rats Respiration / physiology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Drug Combinations; 302-17-0/Chloral Hydrate; 39373-60-9/chloropent; 7487-88-9/Magnesium Sulfate; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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