Document Detail


Equipoise and international human-subjects research.
MedLine Citation:
PMID:  11697388     Owner:  KIE     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper examines the role of equipoise in evaluating international research. It distinguishes two possible formulations of the equipoise requirement that license very different evaluations of international research proposals. The interpretation that adopts a narrow criterion of similarity between clinical contexts has played an important role in one recent controversy, but it suffers from a number of problems. An alternative interpretation that adopts a broader criterion of similarity does a better job of avoiding both exploitation of the brute fact of social deprivation and the exploitation of needy populations for the benefit of more well-off populations. It also holds out the promise of reconciling the need to find interventions that can be employed in developing world contexts with the cluster of moral values that must constrain the way such research is carried out.
Authors:
A J London
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioethics     Volume:  15     ISSN:  0269-9702     ISO Abbreviation:  Bioethics     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-11-06     Completed Date:  2002-08-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8704792     Medline TA:  Bioethics     Country:  England    
Other Details:
Languages:  eng     Pagination:  312-32     Citation Subset:  E    
Affiliation:
Department of Philosophy & Center for the Advancement of Applied Ethics, Carnegie Mellon University, 135 Baker Hall, Pittsburgh, PA 15213, USA. ajlondon@andrew.cmu.edu
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic / standards*
Developed Countries
Developing Countries*
Ethical Analysis*
Ethical Relativism*
Female
HIV Infections / prevention & control,  therapy
Human Experimentation*
Humans
Infectious Disease Transmission, Vertical
Internationality*
Placebos
Pregnancy
Pregnant Women
Research Design*
Research Subjects
Uganda
Uncertainty*
United States
Zidovudine
Chemical
Reg. No./Substance:
0/Placebos; 30516-87-1/Zidovudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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