Document Detail

Equine primary liver tumors: a case series and review of the literature.
MedLine Citation:
PMID:  20224074     Owner:  NLM     Status:  MEDLINE    
Hepatoblastoma (HB) is an uncommon pediatric liver tumor in humans and horses. In humans, HB is most frequently diagnosed in fetuses, neonates, and young children, whereas hepatocellular carcinoma (HCC) affects juvenile and adult humans. Hepatoblastoma in the horse is rare, with only 9 reported cases. Affected horses ranged in age from late-term aborted fetuses to 3 years. The current study describes 3 new cases of primary liver tumors in horses and reviews findings in relation to other reports on this condition. Tumors classified as HB were identified in a male Standardbred aborted fetus and in a 4-year-old Thoroughbred filly. Hepatocellular carcinoma was diagnosed in a 15-month-old Paint filly. In the Standardbred fetus, the tumor was only present in the liver. In the Thoroughbred and Paint fillies, primary tumors were in the right liver lobe and at the hilus, respectively, and there were metastases to other lobes (HB) and mesenteric lymph nodes (HCC). Tumors were sharply demarcated from adjacent tissue, nonencapsulated, compressive, and invasive. Consisting of cords and nests, or disorganized sheets of epithelial cells, tumors had variable stromal and vascular components. The fetal tumor contained areas of smaller, less differentiated cells with a pronounced mesenchymal component interpreted to be embryonal hepatic tissue. Diagnoses were based on tumor histomorphologic features, resemblance to hepatocyte developmental stages, age of the animal, and patterns of metastasis. Tumors classified as HB were alpha-fetoprotein immunoreactive. Primary hepatic tumors in the horse are diverse in morphology and include subtypes compatible with classification criteria applied to human tumors.
Janet Beeler-Marfisi; Luis Arroyo; Jeff L Caswell; Josepha Delay; Dorothee Bienzle
Related Documents :
20371954 - Spontaneous rupture of liver plasmacytoma mimicking hepatocellular carcinoma.
9927494 - Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.
11059864 - In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antis...
11059784 - B16 melanoma cell arrest in the mouse liver induces nitric oxide release and sinusoidal...
2581684 - A human embryonal-yolk sac carcinoma model system in athymic mice.
24137364 - Transformed lymphoplasmacytic lymphoma involving the main carina: a case report.
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc     Volume:  22     ISSN:  1040-6387     ISO Abbreviation:  J. Vet. Diagn. Invest.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011490     Medline TA:  J Vet Diagn Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-83     Citation Subset:  IM    
University of Guelph, Department of Pathobiology, Guelph, Ontario N1G 2W1, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Horse Diseases / pathology*
Liver Neoplasms / pathology,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Type A botulism in horses in the United States: a review of the past ten years (1998-2008).
Next Document:  Prevalence and antigenic differences observed between Bovine viral diarrhea virus subgenotypes isola...