Document Detail


Equine intravenous glucose tolerance test: glucose and insulin responses of healthy horses fed grain or hay and of horses with pituitary adenoma.
MedLine Citation:
PMID:  3516026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous glucose tolerance testing (0.5 g/kg of body weight) was done on 2 groups of healthy horses maintained with hay (group 1, n = 5) and with hay plus grain supplementation (group 2, n = 5) and on a group of horses with clinically diagnosed pituitary adenoma (group 3, n = 10). Healthy horses showed an immediate increase of plasma glucose concentration after the IV glucose injection, with return of values to base line in 1 hour. Group 3 horses showed resting hyperglycemia and a delayed return of glucose values to base line (3 hours). Group 3 horses showed resting hyperinsulinemia and a feeble (nonsignificant) response to the glycemic stimulus, with gradual decrease of insulin values to base line. In addition to the apparently reduced tissue sensitivity to insulin in group 3 horses, as evidenced by hyperglycemia, hyperinsulinemia, and protracted glucose and insulin curves, the initial decrease in the insulin/glucose ratio indicates that there was secretory deficiency in response to acute IV glucose loading.
Authors:
M C Garcia; J Beech
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  47     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-15     Completed Date:  1986-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  570-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenoma / blood,  veterinary*
Animal Feed
Animals
Blood Glucose / analysis*
Cereals
Female
Glucose Tolerance Test / veterinary
Horse Diseases / blood*
Horses / blood*
Insulin / blood*
Male
Orchiectomy
Pituitary Neoplasms / blood,  veterinary*
Poaceae
Reference Values
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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