Document Detail

Equilibrium radionuclide angiocardiography to select inotropic therapy in patients with left ventricular aneurysm.
MedLine Citation:
PMID:  3025819     Owner:  NLM     Status:  MEDLINE    
Fourteen patients with postinfarctual ventricular aneurysm underwent equilibrium radionuclide angiocardiography at rest (ERNA) before and after oral digoxin administration in order to evaluate the effects of increasing myocardial contractility upon both ventricular aneurysm mechanical behaviour and global ventricular function. The ejection fraction (EF) was not significantly affected by digoxin therapy. However, digoxin induced changes in EF (delta EF) correlated inversely with changes in aneurysm size and directly with changes in the extent of the hypokinetic area. Two types of aneurysm were observed: high-compliance aneurysm the size of which increased after digoxin administration while both EF and the extent of the hypokinetic area fell, and low compliance aneurysm for which opposite changes occurred. This different behaviour of ventricular aneurysm may have important practical implications as surgery would be probably more effective than medical treatment in improving resting ventricular function in patients with high-compliance aneurysm.
C L Maini; M G Bonetti; R Antonelli Incalzi; R Pistelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  25     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2007-01-12    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  176-80     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Digoxin / therapeutic use*
Heart Aneurysm / drug therapy,  radionuclide imaging*
Middle Aged
Myocardial Contraction / drug effects*
Myocardial Infarction / complications
Sodium Pertechnetate Tc 99m / diagnostic use
Reg. No./Substance:
20830-75-5/Digoxin; 23288-60-0/Sodium Pertechnetate Tc 99m

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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