Document Detail


Equilibria of humans and our indigenous microbiota affecting asthma.
MedLine Citation:
PMID:  22550247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is becoming increasingly clear that our residential microbes, the key constituents in the human microbiome, are centrally involved in many aspects of our physiology. In particular, the ancient and dominant gastric bacteria Helicobacter pylori are highly interactive with human physiology. In modern times, H. pylori has been disappearing, which consequently affects the interactions between luminal bacteria and epithelial, lymphoid, and neuroendocrine cells. A growing body of evidence indicates that H. pylori protects against childhood-onset asthma, probably through the gastric recruitment of regulatory T cells. The phenomenon of disappearing ancient microbiota may be a general paradigm driving the diseases of modernity.
Authors:
Martin J Blaser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the American Thoracic Society     Volume:  9     ISSN:  1943-5665     ISO Abbreviation:  Proc Am Thorac Soc     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-09-11     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101203596     Medline TA:  Proc Am Thorac Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-71     Citation Subset:  IM    
Affiliation:
Department of Medicine, New York University Langone Medical Center, 550 First Avenue, OBV A606, New York, NY 10016, USA. Martin.Blaser@nyumc.org
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MeSH Terms
Descriptor/Qualifier:
Asthma / immunology*,  microbiology*,  prevention & control
Helicobacter Infections / immunology*
Helicobacter pylori / immunology*
Humans
Metagenome*
Stomach / microbiology
T-Lymphocytes, Regulatory / immunology,  microbiology*
Grant Support
ID/Acronym/Agency:
R01GM63270/GM/NIGMS NIH HHS
Comments/Corrections

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