| Equi-MAC concentrations of halothane and isoflurane do not produce similar bispectral index values. | |
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MedLine Citation:
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PMID: 17413994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Minimum alveolar concentration (MAC) has been traditionally used to measure the potency of an inhalational anesthetic agent. Recently, bispectral index (BIS) derived from the frontal cortical electroencephalogram has been used frequently for quantifying the hypnotic component of anesthesia. The present study was designed to examine the BIS values produced by equi-MAC concentrations of halothane and isoflurane. In 34 patients undergoing spinal surgery, BIS and spectral edge frequency (SEF95) were recorded at 3 different concentrations of halothane and isoflurane--namely 0.5, 0.75, and 1.0 MAC. The measurements were made both during wash-in and wash-out phases of the anesthetic agent. Eighteen patients received halothane and 16 received isoflurane. Heart rate, mean arterial pressure, oxygen saturation, and end tidal carbon dioxide pressure values were not different between the 2 groups at various MAC concentrations of the anesthetic agents. BIS and SEF95 values decreased significantly with increasing concentrations of both the anesthetic agents (P<0.001). At any given MAC concentration of the anesthetic, BIS and SEF(95) values were significantly lower under isoflurane compared with halothane anesthesia both during wash-in and wash-out phases (P<0.001). For a given anesthetic agent, BIS values were comparable at equi-MAC concentrations during wash-in and wash-out phases. In conclusion, BIS values are significantly lower under isoflurane compared with halothane anesthesia at similar MAC concentrations. For a given anesthetic agent and a given MAC concentration, the BIS values are similar during wash-in and wash-out phases of anesthesia. |
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Authors:
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Ganne S Umamaheswara Rao; Zulfiqar Ali; Madhusudan Ramamoorthy; Jayaprakash Patil |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgical anesthesiology Volume: 19 ISSN: 0898-4921 ISO Abbreviation: J Neurosurg Anesthesiol Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-06 Completed Date: 2007-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910749 Medline TA: J Neurosurg Anesthesiol Country: United States |
Other Details:
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Languages: eng Pagination: 93-6 Citation Subset: IM |
Affiliation:
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Department of Neuroanaesthesia, National Institute of Mental Health and Neurosciences, Bangalore, India. gsuma@nimhans.kar.nic.in |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General* Anesthesia, Inhalation* Blood Pressure / drug effects Electroencephalography / drug effects* Female Halothane* / administration & dosage, pharmacokinetics Heart Rate / drug effects Humans Isoflurane* / administration & dosage, pharmacokinetics Male Monitoring, Intraoperative Neurosurgical Procedures Pulmonary Alveoli / metabolism* Spine / surgery |
| Chemical | |
Reg. No./Substance:
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151-67-7/Halothane; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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