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Equation Chapter 1 Section 1Modeling of Oxygen Transport and Cell Killing in Type II Photodynamic Therapy.
MedLine Citation:
PMID:  22443292     Owner:  NLM     Status:  Publisher    
Photodynamic therapy (PDT) provides an effective option for treatment of tumors and other diseases in superficial tissues and attracts attention for in vitro study with cells. In this study we present a significantly improved model of in vitro cell killing through type II PDT for simulation of the molecular interactions and cell killing in time domain in the presence of oxygen transport within a spherical cell. The self-consistency of the approach is examined by determination of conditions for obtaining positive definitive solutions of molecular concentrations. Decay constants of photosensitizers and unoxidized receptors are extracted as the key indices of molecular kinetics with different oxygen diffusion constants and permeability at the cell membrane. By coupling the molecular kinetics to cell killing, we develop a modeling method of PDT cytotoxicity caused by singlet oxygen and obtain the cell survival ratio as a function of light fluence or initial photosensitizer concentration with different photon density or irradiance of incident light and other parameters of oxygen transport. The results show that the present model of type II PDT yields a powerful tool to quantify various events underlying PDT at the molecular and cellular levels and to interpret experimental results of in vitro cell studies. © 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology.
Ioannis Gkigkitzis; Yuanming Feng; Chunmei Yang; Jun Q Lu; Xin-Hua Hu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-24
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  -     ISSN:  1751-1097     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Society for Photobiology.
Departments of Physics Departments of Mathematics, East Carolina University, Greenville, NC 27858, U.S.A. Department of Radiation Oncology, TJMUCH, Tianjin 300060, China Department of Biomedical Engineering, Tianjin University, Tianjin 300072, China.
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