Document Detail

Epstein-Barr virus and human malignancy.
MedLine Citation:
PMID:  190930     Owner:  NLM     Status:  MEDLINE    
The association of the Epstein-Barr virus and two human malignancies, Burkitt's lumphoma and nasopharyngeal carcinoma, is reviewed. Seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the Epstein-Barr virus in these tumors are presented. With our current state of knowledge we cannot conclude that the Ipstein-Barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its association with Burkitt's lymphoma and nasopharyngeal carcinoma.
J L Ziegler; I T Magrath; P Gerber; P H Levine
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of internal medicine     Volume:  86     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-36     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Viral / analysis
Antigens, Viral / analysis
Burkitt Lymphoma / immunology,  microbiology*
Cell Transformation, Neoplastic
DNA, Viral / analysis
Herpesvirus 4, Human / isolation & purification*,  ultrastructure
Infectious Mononucleosis / microbiology
Lymphocytes / microbiology
Membranes / immunology
Nasopharyngeal Neoplasms / immunology,  microbiology*
RNA Viruses
Skin Tests
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/DNA, Viral

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