| Epstein-Barr virus and gastric carcinoma. | |
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MedLine Citation:
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PMID: 11091849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Epstein-Barr virus (EBV) is detected in the tissue of about 10% of gastric carcinoma cases throughout the world. In each case, 100% of carcinoma cells are infected with EBV. Analysis of EBV in carcinoma biopsies indicates that carcinoma is formed by the proliferation of a single EBV infected cell. These findings suggest that EBV plays an important role in the development of EBV positive gastric carcinomas. The EBV genes expressed are EBV determined nuclear antigen 1 (EBNA1), two small non-polyadenylated RNAs known as EBER1 and EBER2, and the transcripts from the BamHI-A region (BARF0); in addition, some cases also express a small amount of latent membrane protein 2A (LMP2A). Epithelial cells are refractory to EBV infection in vitro. This has hampered the study of the role of EBV in epithelial malignancies. The use of recombinant EBV carrying a selectable marker has enabled this difficulty to be overcome. EBV infected cell clones can be obtained from most carcinoma cell lines examined, and it was found that cell to cell contact was an efficient mode of EBV infection. Furthermore, it was possible to immortalize primary gastric epithelial cells by EBV infection. The cells expressed identical EBV genes to those typically seen in EBV positive gastric carcinoma, and showed accelerated malignant properties, including growth in soft agarose and tumorigenicity in severe combined immunodeficient (SCID) mice. These results suggest that EBV contributes to the maintenance of the malignant phenotype of EBV positive gastric carcinoma. |
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Authors:
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K Takada |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Molecular pathology : MP Volume: 53 ISSN: 1366-8714 ISO Abbreviation: MP, Mol. Pathol. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-12-01 Completed Date: 2000-12-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9706282 Medline TA: Mol Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 255-61 Citation Subset: IM |
Affiliation:
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Department of Tumor Virology, Hokkaido University, Sapporo, Japan. kentaka@med.hokudai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers Cell Division / physiology Cell Transformation, Viral / physiology Epithelial Cells / virology Gene Expression Genes, Viral Herpesviridae Infections / complications* Herpesvirus 4, Human / genetics, isolation & purification* Humans Membrane Proteins / physiology Mice Mice, SCID Oncogenic Viruses / genetics RNA, Viral Stomach Neoplasms / virology* Tumor Cells, Cultured Tumor Virus Infections / complications* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Membrane Proteins; 0/RNA, Viral |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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