| Epstein-Barr virus associated with immune thrombocytopenic purpura in childhood: a retrospective study. | |
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MedLine Citation:
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PMID: 11036798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Although Epstein-Barr virus (EBV) is known to cause immune thrombocytopenic purpura (ITP), the epidemiology of this pathogen in children with ITP is not known. In the present study, the clinicoepidemiology and laboratory characteristics of EBV-associated ITP in childhood were analysed retrospectively. METHODS: The study cohort consisted of 108 children in whom ITP was diagnosed between 1990 and 1998. Patients were divided into EBV or non-EBV groups according to their serological status at diagnosis. RESULTS: Thirty-five (32.4%) of 108 children had ITP associated with acute EBV infection. The clinical manifestations and laboratory data were similar in children with and without acute EBV. Responses to various modalities of therapy were analysed. The average time to achieve complete remission (platelet count > or =150 x 10(9)/L) in EBV and non-EBV groups was 26 and 16 days, respectively. CONCLUSIONS: The incidence of childhood ITP associated with acute EBV infection is relatively high in Taiwan. Patients with EBV-associated ITP tended to resolve more slowly than those without EBV infection. |
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Authors:
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C C Hsiao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of paediatrics and child health Volume: 36 ISSN: 1034-4810 ISO Abbreviation: J Paediatr Child Health Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-02-02 Completed Date: 2001-02-02 Revised Date: 2007-09-24 |
Medline Journal Info:
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Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 445-8 Citation Subset: IM |
Affiliation:
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Department of Pediatric Hematology and Oncology, Chang Gung Children's Hospital, Kaohsiung, Taiwan, ROC. chihchenghsiao@sprint.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Catchment Area (Health) Child Child, Preschool Cohort Studies Epstein-Barr Virus Infections / complications*, epidemiology, immunology Female Humans Infant Infant, Newborn Male Platelet Count Prevalence Purpura, Thrombocytopenic, Idiopathic / virology* Retrospective Studies Taiwan / epidemiology |
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