| Epstein-Barr virus-associated primary central nervous system cytotoxic T-cell lymphoma. | |
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MedLine Citation:
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PMID: 23279449 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Primary central nervous system lymphoma (PCNSL) expressing T-cell markers is rare, among which nasal-type extranodal NK/T-cell lymphoma is an extremely rare subtype associated with Epstein-Barr virus (EBV) infection. Here we report the clinicopathologic features of a case of EBV-associated PCNSL showing a cytotoxic T-cell phenotype. The patient, a 73-year-old woman, presented with rapidly progressive mental deterioration. Brain MRI revealed multiple lesions with swelling in the bilateral cerebral hemispheres, which were hypointense on T1-weighted images, hyperintense on T2-weighted and fluid-attenuated inversion recovery images, and slightly hyperintense on diffusion-weighted images. Biopsy specimens from the temporal region showed many medium-sized anaplastic lymphocytic cells with perivascular and angio-invasive patterns in the cortex. Immunohistochemically, the cells were positive for CD3, CD8, T-cell-restricted intracellular antigen-1 (TIA-1), granzyme B and perforin, but negative for CD56 and CD20. In situ hybridization revealed EBV-encoded RNAs in the tumor cell nuclei. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with a clonal appearance. The patient died 6 months after surgery, and a general autopsy revealed no lymphoma cells outside the brain. These cellular profiles are inconsistent with those of extranodal NK/T-cell lymphoma, and have not been previously described. This case appears to represent an unusual CNS manifestation of EBV-associated T-cell lymphoma. |
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Authors:
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Ryosuke Ogura; Hiroshi Aoki; Manabu Natsumeda; Hiroshi Shimizu; Tsutomu Kobayashi; Tomohisa Saito; Jun Takizawa; Kouichirou Okamoto; Go Hasegawa; Hajime Umezu; Kouichi Ohshima; Hitoshi Takahashi; Yukihiko Fujii; Akiyoshi Kakita |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-21 |
Journal Detail:
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Title: Neuropathology : official journal of the Japanese Society of Neuropathology Volume: - ISSN: 1440-1789 ISO Abbreviation: Neuropathology Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606526 Medline TA: Neuropathology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Japanese Society of Neuropathology. |
Affiliation:
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Department of Neurosurgery, University of Niigata, Niigata, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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