Document Detail

Epstein-Barr virus-associated post-transplant primary smooth muscle tumor of the liver: report of an autopsy case.
MedLine Citation:
PMID:  8893230     Owner:  NLM     Status:  MEDLINE    
Epstein-Barr (EB) virus-associated primary smooth muscle tumors have been reported in immunosuppressed young patients with acquired immunodeficiency syndrome (AIDS) and young people who have undergone liver transplantation. An autopsy case of EB virus-associated smooth muscle cell tumor in a 21 year old female who received immunosuppressive therapy following renal transplantation is reported. Multiple tumor nodules were present in the liver, but no primary lesion was found in any other organ. Histologically, the nodules were composed of spindle cells, positive for alpha-smooth muscle actin, which were arranged in fascicles and closely associated with vascular channels, thereby suggesting a vascular smooth muscle cell origin. EB virus infection of the tumor cells was clearly demonstrated by in situ hybridization with an EB virus-encoded RNA 1 (EBER-1) probe. The present case illustrates that EB virus infection may play some role in the development of smooth muscle tumors not only in immunocompromised young patients with liver allografts, but also in those with renal allografts.
Y Sadahira; T Moriya; T Shirabe; T Matsuno; T Manabe
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology international     Volume:  46     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  601-4     Citation Subset:  IM; X    
Department of Pathology, Kawasaki Medical School, Kurashiki, Japan.
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MeSH Terms
Fatal Outcome
Herpesvirus 4, Human / isolation & purification*,  pathogenicity
Kidney Transplantation / adverse effects*
Liver Neoplasms / etiology*,  virology*
Smooth Muscle Tumor / etiology,  pathology*,  virology*

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