Document Detail

Review article: epoxyeicosatrienoic acids: novel mediators of cardioprotection.
MedLine Citation:
PMID:  20200327     Owner:  NLM     Status:  MEDLINE    
Recent evidence from a number of in vitro and in vivo studies in isolated cells and animal models has suggested that the cytochrome P450 (CYP450) pathway of arachidonic acid (AA) metabolism produces potent cardioprotective metabolites that markedly reduce reversible (myocardial stunning) and irreversible (infarct size [IS]) injury in the ischemic/reperfused heart. The major players in this protective response appear to be the AA metabolites including the regioisomers of 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs). The present review article will discuss the beneficial effects of the EETs on myocardial stunning and IS reduction and consider some of the signaling pathways and cellular mechanisms by which the EETs produce their beneficial effects and the possible therapeutic benefits that may result from activation of this pathway. The results discussed in this review are taken from experiments obtained from 3 diverse species in different laboratories: the mouse, rat, and dog, in which the results were nearly identical qualitatively and quantitatively, suggesting that these findings are likely to be extrapolated to man as well.
Kasem Nithipatikom; Garrett J Gross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-03-03
Journal Detail:
Title:  Journal of cardiovascular pharmacology and therapeutics     Volume:  15     ISSN:  1940-4034     ISO Abbreviation:  J. Cardiovasc. Pharmacol. Ther.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602617     Medline TA:  J Cardiovasc Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
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MeSH Terms
Arachidonic Acid / metabolism
Arachidonic Acids / metabolism*
Cytochrome P-450 Enzyme System / metabolism
Mitochondria / metabolism
Myocardial Infarction / metabolism*,  physiopathology
Myocardial Reperfusion Injury / metabolism*,  physiopathology,  prevention & control
Myocardial Stunning / metabolism*,  physiopathology
Natriuretic Peptide, Brain / metabolism
Grant Support
Reg. No./Substance:
0/Arachidonic Acids; 114471-18-0/Natriuretic Peptide, Brain; 506-32-1/Arachidonic Acid; 9035-51-2/Cytochrome P-450 Enzyme System

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