| Epoprostenol in chronic thromboembolic pulmonary hypertension with distal lesions. | |
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MedLine Citation:
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PMID: 15554033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although patients with primary pulmonary hypertension and patients with chronic thromboembolic pulmonary hypertension with distal lesions may share similar pathophysiological characteristics, scarce information is available on the usefulness of epoprostenol in this form of secondary pulmonary hypertension. The aim of this study was to evaluate the feasibility, safety and efficacy of epoprostenol therapy in surgically untreatable patients with chronic thromboembolic pulmonary hypertension. METHODS: Continuous infusive therapy with epoprostenol was undertaken in 16 patients with primary pulmonary hypertension and in 11 surgically untreatable thromboembolic pulmonary hypertension patients. The median follow-up was 12.4 months (range 6-23 months). Patients underwent clinical, echocardiographic and hemodynamic evaluation at baseline and a 6-min walk test every 3 months after beginning epoprostenol; ultrasound evaluations were repeated in a subgroup of patients. RESULTS: Epoprostenol therapy improved the clinical status, exercise tolerance and NYHA functional class. A greater left ventricular end-diastolic volume was recorded at echocardiography in both groups. CONCLUSIONS: Epoprostenol therapy may be feasible, safe and clinically effective in patients with surgically untreatable chronic thromboembolic pulmonary hypertension. |
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Authors:
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Laura Scelsi; Stefano Ghio; Carlo Campana; Andrea Maria D'Armini; Alessandra Serio; Catherine Klersy; Franco Piovella; Mario Viganò; Luigi Tavazzi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian heart journal : official journal of the Italian Federation of Cardiology Volume: 5 ISSN: 1129-471X ISO Abbreviation: Ital Heart J Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909716 Medline TA: Ital Heart J Country: Italy |
Other Details:
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Languages: eng Pagination: 618-23 Citation Subset: IM |
Affiliation:
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Division of Cardiology, IRCCS Policlinico San Matteo, Pavia, Italy. l.scelsi@smatteo.pv.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Echocardiography, Doppler Epoprostenol / therapeutic use* Exercise Tolerance Feasibility Studies Female Heart Catheterization Humans Hypertension, Pulmonary / complications, drug therapy* Infusions, Intravenous Male Middle Aged Platelet Aggregation Inhibitors / therapeutic use* Regression Analysis Thromboembolism / complications, drug therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Platelet Aggregation Inhibitors; 35121-78-9/Epoprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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