| Epoprostenol improves mucosal tissue oxygen tension in an acute endotoxemic pig model. | |
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MedLine Citation:
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PMID: 18520707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the present study was to determine the effects of increasing dosages of continuously infused epoprostenol (PGI), a prostacyclin analog, on intestinal oxygen supply and jejunal mucosal tissue oxygen tension in an acute endotoxic pig model. Jejunal mucosal tissue PO2, oxygen saturation of jejunal microvascular hemoglobin, and gut microvascular blood flow were investigated. Systemic hemodynamic variables, mesenteric-venous and systemic acid base and blood gas variables, and lactate measurements were recorded. Measurements were performed at baseline, after Escherichia coli LPS administration, and at 20-min intervals during incremental PGI infusion (n = 8; 25, 50, 100, and 200microg x kg x h, respectively); or infusion of an equal amount of isotonic sodium chloride solution (n = 7). LPS infusion led to a significant decrease in mucosal tissue oxygen tension and microvascular hemoglobin oxygen saturation. Epoprostenol infusion led to a significant, dose-dependent increase in cardiac index and systemic oxygen delivery. Mucosal tissue oxygen tension and microvascular hemoglobin oxygen saturation increased after PGI administration and even returned to more-than-baseline values. Continuously infused PGI increased intestinal hemoglobin oxygen saturation and mucosal tissue oxygen tension in a dose-dependent manner mainly due to an increase in villus blood flow in this acute endotoxic pig model. |
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Authors:
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Stephan Maier; Werner Pajk; Hanno Ulmer; Hans Hausdorfer; Christian Torgersen; Josef Klocker; Walter Hasibeder; Hans Knotzer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 31 ISSN: 1540-0514 ISO Abbreviation: Shock Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: United States |
Other Details:
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Languages: eng Pagination: 104-10 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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drug effects Acute Disease Animals Antihypertensive Agents / pharmacology* Blood Gas Analysis Disease Models, Animal Dose-Response Relationship, Drug Endotoxemia / drug therapy, metabolism, physiopathology* Epoprostenol / pharmacology* Escherichia coli / chemistry Female Hemoglobins Intestinal Mucosa / blood supply*, metabolism, physiopathology* Jejunum / blood supply, metabolism, physiopathology Lipopolysaccharides / chemistry, toxicity* Male Oxygen / metabolism* Oxygen Consumption / drug effects* Rats |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Hemoglobins; 0/Lipopolysaccharides; 35121-78-9/Epoprostenol; 7782-44-7/Oxygen |
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