| Epoetin beta: new indication. Preparation for IV-SC injection: erythrocyte growth factor. | |
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MedLine Citation:
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PMID: 10183393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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According to an unreliable meta-analysis, epoetin beta reduces the number of premature neonates needing transfusions for anaemia by 18% on average. When such children do require transfusions, two comparative trials have shown a reduction in the frequency of transfusions and total volume of blood transfused, but the clinical consequences were not studied. Thus clinical experience to date is too limited to rule out a risk of possibly severe adverse events. Furthermore, prescription of epoetin beta must be accompanied by iron supplementation, whose optimal dose and route of administration have not been established. The cost-benefit ratio of epoetin beta in the prevention of anaemia in premature infants must be thoroughly assessed in the context of national health systems. |
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Authors:
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Prescrire international Volume: 7 ISSN: 1167-7422 ISO Abbreviation: Prescrire Int Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-09-24 Completed Date: 1998-09-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9439295 Medline TA: Prescrire Int Country: FRANCE |
Other Details:
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Languages: eng Pagination: 13-5 Citation Subset: T |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Neonatal
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prevention & control* Blood Transfusion Clinical Trials as Topic Cost-Benefit Analysis Erythropoietin* / administration & dosage, adverse effects, therapeutic use France Humans Infant, Newborn Infant, Premature Infection / chemically induced Iron / deficiency Iron, Dietary Meta-Analysis as Topic Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Iron, Dietary; 11096-26-7/Erythropoietin; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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