Document Detail

Epoetin beta: new indication. Preparation for IV-SC injection: erythrocyte growth factor.
MedLine Citation:
PMID:  10183393     Owner:  NLM     Status:  MEDLINE    
According to an unreliable meta-analysis, epoetin beta reduces the number of premature neonates needing transfusions for anaemia by 18% on average. When such children do require transfusions, two comparative trials have shown a reduction in the frequency of transfusions and total volume of blood transfused, but the clinical consequences were not studied. Thus clinical experience to date is too limited to rule out a risk of possibly severe adverse events. Furthermore, prescription of epoetin beta must be accompanied by iron supplementation, whose optimal dose and route of administration have not been established. The cost-benefit ratio of epoetin beta in the prevention of anaemia in premature infants must be thoroughly assessed in the context of national health systems.
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  7     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-09-24     Completed Date:  1998-09-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  13-5     Citation Subset:  T    
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MeSH Terms
Anemia, Neonatal / prevention & control*
Blood Transfusion
Clinical Trials as Topic
Cost-Benefit Analysis
Erythropoietin* / administration & dosage,  adverse effects,  therapeutic use
Infant, Newborn
Infant, Premature
Infection / chemically induced
Iron / deficiency
Iron, Dietary
Meta-Analysis as Topic
Treatment Outcome
Reg. No./Substance:
0/Iron, Dietary; 11096-26-7/Erythropoietin; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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