Document Detail


Epoetin alfa therapy for anaemia in HIV-infected patients: impact on quality of life.
MedLine Citation:
PMID:  11057937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the effect of epoetin alfa on the quality of life (QOL) of HIV-infected patients in the community setting, 221 anaemic (haemoglobin < or = 11 g/dl) HIV-positive patients from community-based treatment centres and physicians' offices were treated with epoetin alfa (100-300 units/kg subcutaneously 3 times a week) in a 4-month, open-label, non-randomized, phase IV trial. Epoetin alfa therapy significantly (P<0.01) increased and maintained haemoglobin levels (mean increase=2.5 g/dl; n=207); the improvement in haemoglobin levels was independent of changes in CD4+ cell counts. Transfusion requirements were also significantly reduced from 20% to 5% of patients (P<0.01). Mean total QOL score measured by the Functional Assessment of HIV Infection (FAHI) scale and Physical Well-Being subscale score improved significantly (P<0.05). QOL improvements associated with increases in haemoglobin were independent of changes in CD4+ counts and baseline anaemia severity. Adverse events observed during epoetin alfa therapy were consistent with HIV disease and not likely due to the drug. Epoetin alfa therapy should be considered a treatment option for HIV-infected patients with mild-to-moderate anaemia.
Authors:
D I Abrams; C Steinhart; R Frascino
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase IV; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of STD & AIDS     Volume:  11     ISSN:  0956-4624     ISO Abbreviation:  Int J STD AIDS     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-29     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007917     Medline TA:  Int J STD AIDS     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  659-65     Citation Subset:  IM; X    
Affiliation:
UCSF Positive Health Program, San Francisco General Hospital, California 94110, USA. dabrams@php.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / blood,  prevention & control*
Epoetin Alfa / therapeutic use*
Female
HIV Infections / blood,  complications,  drug therapy*
Hematinics / therapeutic use*
Hemoglobins / analysis
Humans
Male
Quality of Life
Chemical
Reg. No./Substance:
0/Hematinics; 0/Hemoglobins; 113427-24-0/Epoetin Alfa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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