| Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries. | |
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MedLine Citation:
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PMID: 11468211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Coronary artery angioplasty triggers healing that causes constrictive remodeling. Because collagen accumulation correlates with constrictive remodeling and aldosterone has been implicated in collagen accumulation, we examined how aldosterone and the mineralocorticoid receptor antagonists spironolactone and eplerenone affect remodeling and collagen in porcine coronary and iliac arteries after angioplasty. METHODS AND RESULTS: Twenty-four pigs were allocated into 4 treatment groups: oral eplerenone (100 mg/d), oral spironolactone (200 mg/d), subcutaneous aldosterone (400 microgram/d), or no treatment. Twenty-eight days after angioplasty of the coronary arteries, eplerenone increased total vessel area by 30% (P<0.05) and luminal area by nearly 60% (P<0.05) compared with the no-treatment group, without affecting neointima size. These effects were accompanied by a 65% reduction in neointimal and medial collagen density (both P<0.05). Spironolactone was less effective, and aldosterone tended to exert opposite effects on coronary artery structure after angioplasty. These effects were not observed in angioplastied iliac arteries. CONCLUSIONS: Eplerenone attenuates constrictive remodeling after coronary artery angioplasty by mechanisms involving reduction in collagen accumulation, which thus appears to be an important contributor to constrictive remodeling of angioplastied coronary arteries. |
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Authors:
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M R Ward; P Kanellakis; D Ramsey; J Funder; A Bobik |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 104 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-24 Completed Date: 2001-09-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 467-72 Citation Subset: AIM; IM |
Affiliation:
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Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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pharmacology Aldosterone Antagonists / pharmacology* Angioplasty, Balloon / adverse effects Animals Collagen / drug effects*, metabolism Constriction, Pathologic / prevention & control Coronary Disease / etiology, metabolism, prevention & control Coronary Vessels / drug effects*, injuries, metabolism Elastin / drug effects, metabolism Iliac Artery / drug effects, injuries, metabolism Male Spironolactone / analogs & derivatives, pharmacology* Swine Swine, Miniature Tunica Intima / drug effects, pathology |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/eplerenone; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 9007-34-5/Collagen; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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