| Epitopes immunologically related to glycophorin A on human malignant and non-malignant cells in culture. | |
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MedLine Citation:
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PMID: 6210254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine monoclonal antibodies specific to different antigenic determinants on the cyanogen bromide fragments CNBr3 (1-8) and CNBr1 (9-81) of glycophorin A, the major sialoglycoprotein of human red blood cells, were used for the detection of similar or cross-reactive epitope(s) on nucleated somatic cells. A panel of human malignant and non-malignant cells consisting of erythroleukemia, melanoma and carcinomas of breast, cervix, larynx, nasopharynx and colon, as well as human fibroblasts and mammary cells, were tested using a sensitive enzyme-linked immunoassay. The presence of glycophorin-like epitopes were demonstrated, in varying concentrations, on all cells tested. These epitropes were found to be localized on the cell membranes by indirect immunofluorescence. |
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Authors:
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A L Barsoum; M S Czuczman; V P Bhavanandan; E A Davidson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 34 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-11 Completed Date: 1985-02-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: DENMARK |
Other Details:
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Languages: eng Pagination: 789-95 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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immunology Cells, Cultured Epitopes / analysis* Female Fluorescent Antibody Technique Glycophorin / analysis*, immunology Humans Immunoenzyme Techniques Neoplasms / immunology* Radioimmunoassay Sialoglycoproteins / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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CA 15483/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Epitopes; 0/Glycophorin; 0/Sialoglycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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