| Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis. | |
| | |
MedLine Citation:
|
PMID: 20059480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Anti-neutrophil cytoplasmic antibodies against proteinase 3 (PR3-ANCA) are used as diagnostic tools for patients with small vessel vasculitis (AASV). We have produced chimeric mouse/human PR3 molecules and investigate changes in reactivity over time and the possible relationship between epitope specificity and clinical course. Thirty-eight PR3-ANCA-positive patients diagnosed between 1990 and 2003 were followed until December 2005. Plasma was collected at each out-patient visit and older samples were retrieved retrospectively. Patients reacted with multiple epitopes at the time of diagnosis. At subsequent relapses 12 patients shifted reactivity, in 11 cases from epitopes located in the C-terminal towards epitopes in the N-terminal. Patients with reactivity against N-terminal parts of PR3 at diagnosis had a significantly lower relapse rate, 30% compared to 78% in the group with predominantly C-terminal reactivity (P = 0.04). The reactivity pattern did not correlate to outcome measured as death, end-stage renal disease or vasculitis activity index score (VDI) at 5 years. Further research is necessary to conclude if this is a general phenomenon. |
| | |
Authors:
|
D Selga; M Segelmark; L Gunnarsson; T Hellmark |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-01-06 |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 160 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-18 Completed Date: 2010-07-09 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 318-24 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Clinical Sciences in Lund, Lund University and Lund University Hospital, Sweden. Daina.Selga@med.lu.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Antibodies, Antineutrophil Cytoplasmic / blood, immunology* Antibody Specificity / immunology* Autoimmune Diseases / blood, immunology*, mortality, therapy Child Epitopes / immunology*, metabolism Female Humans Male Middle Aged Myeloblastin / immunology*, metabolism Prospective Studies Protein Structure, Tertiary Retrospective Studies Vasculitis / blood, immunology*, mortality, therapy |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antineutrophil Cytoplasmic; 0/Epitopes; EC 3.4.21.76/Myeloblastin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways...
Next Document: Islet inflammation and CXCL10 in recent-onset type 1 diabetes.