Document Detail

Epithelioid perineurioma: an unusual variant.
MedLine Citation:
PMID:  18820102     Owner:  NLM     Status:  MEDLINE    
An unusual epithelioid variant of perineurioma of the groin occurring in a 53-year-old man is described. The lesion appeared to be associated with a femoral nerve branch. The tumour was characterised by the presence of a syncytial proliferation of epithelioid cells, mimicking a meningioma of syncytial type. In addition there was a minor component of a conventional perineurioma. The tumour cells were EMA+, claudin-1+ and collagen type IV+. Bcl 2 was focally expressed. This case highlights the possibility of a common histogenetic pathway for meningiomas and perineuriomas. Although ultrastructural evidence of possible meningiomatous differentiation within an otherwise histologically typical perineurioma has been described, this is the first reported case of an unconventional epithelioid variant of perineurioma, histologically resembling meningioma.
S A Haider; R J Lemberger; C Fisher; T A McCulloch
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  61     ISSN:  1472-4146     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2008-10-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1130-2     Citation Subset:  AIM; IM    
Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
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MeSH Terms
Collagen Type IV / analysis
Epithelioid Cells / pathology*
Femoral Nerve*
Femoral Neuropathy / pathology*,  surgery
Membrane Proteins / analysis
Middle Aged
Mucin-1 / analysis
Nerve Sheath Neoplasms / chemistry,  pathology*,  surgery
Peripheral Nervous System Neoplasms / pathology*,  surgery
Reg. No./Substance:
0/Collagen Type IV; 0/Membrane Proteins; 0/Mucin-1; 0/claudin 1

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