| Epithelioid cell histiocytoma--histogenetic and kinetics analysis of dermal microvascular unit dendritic cell subpopulations. | |
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MedLine Citation:
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PMID: 12859738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epithelioid cell histiocytoma (ECH), also known as epithelioid fibrous histiocytoma, is a peculiar dermal tumor, which can mimic melanocytic, vascular, epithelial, or other histiocytic lesions. Thought to arise from dermal dendrocytes, most ECH contain approximately 50% FXIIIa+ histiocytic dendrocytes, but not all lesional cells express FXIIIa. A putative fibroblastic component has not been characterized. METHODS: We analyzed the differentiation and cell kinetics of dermal microvascular unit cells in 12 previously reported ECH using antibodies to FXIIIa, CD68 (KP1), CD34, CD117, CD31, smooth muscle actin, collagen type 1 aminopropeptide, and MIB-1, using single and double immunostains. RESULTS: In ECH, many variably sized CD34/CD31+ tumor vessels with actin+ myopericytes were surrounded by epithelioid-to-dendritic cells of three types. About 5-80% were dendritic histiocytes that expressed FXIIIa but not CD31 or KP1. Fibroblasts, in some cases showing mild nuclear pleomorphism, were usually collagen type 1+, but CD34 and actin- in 11/12 cases. One 'early' ECH had 40% CD34+ epithelioid cells, admixed with 50% FXIIIa+ histiocytes. Most ECH had about 2-20% KP1+, CD117+ mast cells. Mast cell numbers increased with FXIIIa+ histiocyte numbers and the intensity of FXIIIa expression. MIB-1/FXIIIa double-labeling showed only rare cycling histiocytes, with numerous cycling fibroblasts and endothelial cells. CONCLUSIONS: Our findings support the impression that ECH is a vascular fibrous histiocytoma. The constituent cells appear to arise from the activation of resident microvascular CD34+ dermal fibroblasts and the accumulation of FXIIIa+ dendritic stromal assembly histiocytes. The CD34+ cells appear to differentiate toward collagenous fibrocytes in association with histiocytes and mast cells in forming collagenous stroma and vessels. ECH is a tumor composed of all requisite cell types consistent with the origin from the dermal microvascular unit. |
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Authors:
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Jeffrey S Silverman; Earl J Glusac |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 30 ISSN: 0303-6987 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-15 Completed Date: 2004-03-17 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
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Languages: eng Pagination: 415-22 Citation Subset: IM |
Affiliation:
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Southside Hospital, Department of Pathology, Bay Shore, NY, USA. peptolab@hamptons.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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metabolism Cell Count Cell Transformation, Neoplastic / pathology* Dendritic Cells / metabolism, pathology* Epithelioid Cells / metabolism, pathology* Factor XIII / metabolism Histiocytoma, Benign Fibrous / metabolism, pathology* Humans Immunoenzyme Techniques Kinetics Skin Neoplasms / metabolism, pathology* Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Tumor Markers, Biological; 104641-95-4/factor XIII subunit A; 9013-56-3/Factor XIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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